Age and cigarette smoking are independently associated with the cutaneous vascular response to local warming
Age and cigarette smoking are independently associated with the cutaneous vascular response to local warming
Purpose: to investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion.
Experimental design: skin blood flux was measured before and during the hyperaemic response to thermal warming of the skin to 43°C using laser Doppler fluximetry (LDF) in 28 habitual smokers (5.4 [11.4] (median [IQR]) pack years; pack years=packs/day times duration of smoking habit), aged between 18 and 63 years and their age, sex and body mass index. Flow motion was assessed using Fourier analysis of the LDF signal.
Results: mean and total hyperaemic (area under the flux curve, AUC10) response during warming were reduced in smokers compared with their non-smoking controls (P<0.05). Attenuation of the response to warming in smokers was associated with a reduction in relative spectral power around 0.01 Hz, reflecting a reduced endothelial/metabolic activity (P<0.04). In regression modelling with AUC10 as the outcome, and smoking (yes/no), age, sex and BMI, as explanatory variables, age (P<0.0001) and smoking (P<0.018) were independently associated with the hyperaemic response and together accounted for 31% of the variance in AUC10.
Conclusions: age and smoking are associated with approximately one-third of the variance in the endothelium-associated microvascular vasomotor activity in habitual smokers
chronic cigarette smoking, age, skin blood flow motion, warming, laser doppler flowmetry
725-734
Avery, Miriam R.
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Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
November 2009
Avery, Miriam R.
f92866a0-096b-47f4-a63f-8b651164eee9
Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Avery, Miriam R., Voegeli, David, Simpson, David, Clough, Geraldine F. and Byrne, Christopher D.
(2009)
Age and cigarette smoking are independently associated with the cutaneous vascular response to local warming.
Microcirculation, 16 (8), .
(doi:10.3109/10739680903199194).
Abstract
Purpose: to investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion.
Experimental design: skin blood flux was measured before and during the hyperaemic response to thermal warming of the skin to 43°C using laser Doppler fluximetry (LDF) in 28 habitual smokers (5.4 [11.4] (median [IQR]) pack years; pack years=packs/day times duration of smoking habit), aged between 18 and 63 years and their age, sex and body mass index. Flow motion was assessed using Fourier analysis of the LDF signal.
Results: mean and total hyperaemic (area under the flux curve, AUC10) response during warming were reduced in smokers compared with their non-smoking controls (P<0.05). Attenuation of the response to warming in smokers was associated with a reduction in relative spectral power around 0.01 Hz, reflecting a reduced endothelial/metabolic activity (P<0.04). In regression modelling with AUC10 as the outcome, and smoking (yes/no), age, sex and BMI, as explanatory variables, age (P<0.0001) and smoking (P<0.018) were independently associated with the hyperaemic response and together accounted for 31% of the variance in AUC10.
Conclusions: age and smoking are associated with approximately one-third of the variance in the endothelium-associated microvascular vasomotor activity in habitual smokers
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Published date: November 2009
Keywords:
chronic cigarette smoking, age, skin blood flow motion, warming, laser doppler flowmetry
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Local EPrints ID: 72684
URI: http://eprints.soton.ac.uk/id/eprint/72684
ISSN: 1073-9688
PURE UUID: 8611ca77-967d-4b76-8cfd-2b60b75c726c
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Date deposited: 19 Feb 2010
Last modified: 14 Mar 2024 02:47
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Author:
Miriam R. Avery
Author:
David Voegeli
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