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Different indicies of fetal growth predict bone size and volumetric density at 4 years old

Different indicies of fetal growth predict bone size and volumetric density at 4 years old
Different indicies of fetal growth predict bone size and volumetric density at 4 years old
We have previously demonstrated that higher birth-weight is associated with greater peak and later life bone mineral, and that maternal body build, diet and lifestyle influence prenatal bone mineral accrual. To examine further prenatal influences on bone health we related ultrasound measures of fetal growth to childhood bone size and density. We derived Z-scores for fetal femur length and abdominal circumference and conditional growth velocity from 19-34 weeks gestation from ultrasound measurements in participants in the Southampton Women's Survey. 380 of the offspring underwent dual-energy X-ray absorptiometry at age 4-years [whole body minus head bone area (BA), bone mineral content (BMC), areal bone mineral density (aBMD) and estimated volumetric BMD (vBMD)]. Volumetric bone mineral density was estimated using BMC adjusted for BA, height and weight. A higher velocity of 19-34 week fetal femur growth was strongly associated with greater childhood skeletal size (BA: r=0.30, p<0.0001) but not with volumetric density (vBMD: r=0.03, p=0.51). Conversely, a higher velocity of 19-34 week fetal abdominal growth was associated with greater childhood volumetric density (vBMD: r=0.15, p=0.004) but not with skeletal size (BA: r=0.06, p=0.21). Both fetal measurements were positively associated with BMC and aBMD, indices influenced by both size and density. The velocity of fetal femur length growth from 19-34 weeks gestation predicted childhood skeletal size at age 4-years whereas the velocity of abdominal growth (a measure of liver volume and adiposity) predicted volumetric density. These results suggest a discordance between influences on skeletal size and volumetric density.
0884-0431
1-32
Harvey, N.
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Mahon, P.
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Robinson, S.
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Nisbet, C.
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Javaid, M.
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Crozier, S.
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Inskip, H.
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Godfrey, K.
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Arden, N.
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Dennison, E.
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Cooper, C.
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Harvey, N.
ce487fb4-d360-4aac-9d17-9466d6cba145
Mahon, P.
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Robinson, S.
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Nisbet, C.
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Javaid, M.
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Crozier, S.
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Inskip, H.
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Godfrey, K.
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Arden, N.
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Dennison, E.
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Cooper, C.
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Harvey, N., Mahon, P., Robinson, S., Nisbet, C., Javaid, M., Crozier, S., Inskip, H., Godfrey, K., Arden, N., Dennison, E. and Cooper, C. (2010) Different indicies of fetal growth predict bone size and volumetric density at 4 years old. Journal of Bone and Mineral Research, 25 (4), 1-32. (doi:10.1359/jbmr.091022).

Record type: Article

Abstract

We have previously demonstrated that higher birth-weight is associated with greater peak and later life bone mineral, and that maternal body build, diet and lifestyle influence prenatal bone mineral accrual. To examine further prenatal influences on bone health we related ultrasound measures of fetal growth to childhood bone size and density. We derived Z-scores for fetal femur length and abdominal circumference and conditional growth velocity from 19-34 weeks gestation from ultrasound measurements in participants in the Southampton Women's Survey. 380 of the offspring underwent dual-energy X-ray absorptiometry at age 4-years [whole body minus head bone area (BA), bone mineral content (BMC), areal bone mineral density (aBMD) and estimated volumetric BMD (vBMD)]. Volumetric bone mineral density was estimated using BMC adjusted for BA, height and weight. A higher velocity of 19-34 week fetal femur growth was strongly associated with greater childhood skeletal size (BA: r=0.30, p<0.0001) but not with volumetric density (vBMD: r=0.03, p=0.51). Conversely, a higher velocity of 19-34 week fetal abdominal growth was associated with greater childhood volumetric density (vBMD: r=0.15, p=0.004) but not with skeletal size (BA: r=0.06, p=0.21). Both fetal measurements were positively associated with BMC and aBMD, indices influenced by both size and density. The velocity of fetal femur length growth from 19-34 weeks gestation predicted childhood skeletal size at age 4-years whereas the velocity of abdominal growth (a measure of liver volume and adiposity) predicted volumetric density. These results suggest a discordance between influences on skeletal size and volumetric density.

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Published date: April 2010
Organisations: Faculty of Medicine, Dev Origins of Health & Disease

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Local EPrints ID: 72749
URI: http://eprints.soton.ac.uk/id/eprint/72749
ISSN: 0884-0431
PURE UUID: 6741ced4-a483-41ce-93b3-5ba960db6eba
ORCID for N. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for S. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for H. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for E. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 24 Feb 2010
Last modified: 18 Feb 2021 17:02

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Contributors

Author: N. Harvey ORCID iD
Author: P. Mahon
Author: S. Robinson ORCID iD
Author: C. Nisbet
Author: M. Javaid
Author: S. Crozier
Author: H. Inskip ORCID iD
Author: K. Godfrey ORCID iD
Author: N. Arden
Author: E. Dennison ORCID iD
Author: C. Cooper ORCID iD

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