The University of Southampton
University of Southampton Institutional Repository

Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets

Hyde, Matthew J., Griffin, Julian L., Herrera, Emilio, Byrne, Christopher D., Clarke, Lynne and Kemp, Paul R. (2010) Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets Clinical Science, 118, (1), pp. 47-59. (doi:10.1042/CS20090169).

Record type: Article


There has been a marked increase in the number of babies born by elective CS (Caesarean section). Following CS, the lack of normal stimuli that occur at birth alters the thermogeneic response, but any effects on hepatic metabolism have not been identified. In the present study, we compared the effect of delivery on hepatic metabolism in piglets, born either by CS or VD (vaginal delivery) and fed by TPN (total parenteral nutrition), by measuring lipid metabolism and enzyme activity coupled with metabolomic and genomic approaches. Hepatic lipid in the CS piglets at 7 days post-partum was in excess of 5 mg/g of liver consistent with hepatic steatosis, whereas in the VD piglets the amount of lipid was markedly lower (3 mg/g of liver) and below the threshold for a diagnosis of steatosis. Metabolomic analysis indicated that CS resulted in higher hepatic glycerol and lower glycerol phosphate dehydrogenase activity, suggesting that CS causes a decrease in hepatic gluconeogenesis from glycerol. CS also resulted in altered cholesterol handling and gene expression, despite the same dietary intake for 7 days post-partum. Furthermore, the CS piglets had a lower expression of interferon-responsive genes, but a higher expression of markers of immature hepatocytes. In conclusion, the results suggest that VD promotes normal liver maturation and hepatic metabolism, thereby reducing the accumulation of hepatic lipid.

PDF 1180047.pdf - Version of Record
Restricted to Repository staff only
Download (434kB)

More information

Published date: January 2010
Keywords: birth, caesarean section, liver, metabolic syndrome, steatosis, total parenteral nutrition (tpn)


Local EPrints ID: 72753
ISSN: 0143-5221
PURE UUID: 7a9725d5-56bc-4998-b382-3dfc167fdae9

Catalogue record

Date deposited: 22 Feb 2010
Last modified: 18 Jul 2017 23:53

Export record



Author: Matthew J. Hyde
Author: Julian L. Griffin
Author: Emilio Herrera
Author: Lynne Clarke
Author: Paul R. Kemp

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.