Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure
Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure
By incorporating ferrocene into the hydrophobic membrane of PEG-b-PCL polymersome nanoparticles it is possible to selectively visualize their core using Transmission Electron Microscopy (TEM). Two different sizes of ferrocene-loaded polymersomes with mean hydrodynamic diameters of approximately 40 and 90 nm were prepared. Image analysis of TEM pictures of these polymersomes found that the mean diameter of the core was 4-5 times smaller than the mean hydrodynamic diameter. The values obtained also allow the surface diameter and internal volume of the core to be calculated.
nanoparticle, characterization, pharmacokinetics, polymersomes, peg, pcl, tem
Johnston, Alexander H.
b3325b84-67c4-4d9c-ba97-57f2fdf017ba
Dalton, Paul D.
b0764bcb-54fe-4fdb-96f5-957a81567029
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
University of Southampton
August 2010
Johnston, Alexander H.
b3325b84-67c4-4d9c-ba97-57f2fdf017ba
Dalton, Paul D.
b0764bcb-54fe-4fdb-96f5-957a81567029
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Johnston, Alexander H., Dalton, Paul D. and Newman, Tracey A.
,
University of Southampton
(2010)
Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure.
Journal of Nanoparticle Research, 12 (6).
(doi:10.1007/s11051-010-9886-5).
Abstract
By incorporating ferrocene into the hydrophobic membrane of PEG-b-PCL polymersome nanoparticles it is possible to selectively visualize their core using Transmission Electron Microscopy (TEM). Two different sizes of ferrocene-loaded polymersomes with mean hydrodynamic diameters of approximately 40 and 90 nm were prepared. Image analysis of TEM pictures of these polymersomes found that the mean diameter of the core was 4-5 times smaller than the mean hydrodynamic diameter. The values obtained also allow the surface diameter and internal volume of the core to be calculated.
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ahj-Polymersomes.pdf
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Submitted date: 22 February 2010
Published date: August 2010
Keywords:
nanoparticle, characterization, pharmacokinetics, polymersomes, peg, pcl, tem
Identifiers
Local EPrints ID: 72760
URI: http://eprints.soton.ac.uk/id/eprint/72760
ISSN: 1388-0764
PURE UUID: 15291ab8-a7ee-491c-8ceb-0d40189bbf95
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Date deposited: 24 Feb 2010
Last modified: 14 Mar 2024 02:39
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Author:
Alexander H. Johnston
Author:
Paul D. Dalton
Corporate Author: University of Southampton
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