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The Chest radiograph appearences of very premature infants at 36 weeks post- conceptional age

The Chest radiograph appearences of very premature infants at 36 weeks post- conceptional age
The Chest radiograph appearences of very premature infants at 36 weeks post- conceptional age
The chest radiograph of very premature infants at 36 weeks post-conceptional age (PCA) was evaluated with regard to the degree of hyperinflation and cardiomegaly, and the presence of fibrosis/interstitial shadowing, cystic elements, air bronchograms and opacification. The evolution of abnormalities was assessed by comparing the radiograph appearance at 36 weeks PCA with that at 28 days post-natal age (PNA). Three scoring systems were used to determine how any abnormalities present could be best quantified to reflect disease severity as determined by chronic dependency upon supplementary oxygen status. Chest radiographs at 36 weeks PCA from 60 infants (median gestational age 26 weeks (range 24-28)) were studied. 47 infants also had radiographs at 28 days PNA. Only three infants had no chest radiograph abnormalities at 36 weeks PCA, although 24 infants were not dependent upon supplementary oxygen. The most common abnormalities were interstitial shadowing and hyperinflation, while cystic elements and cardiomegaly were rare. The radiographic appearance had deteriorated from 28 days PNA to 36 weeks PCA (p < 0.05); more infants at 36 weeks PCA were hyperinflated (p < 0.01). The chest radiograph appearances of infants who were dependent upon supplementary oxygen scored higher than those who were not (p < 0.01) using all three scoring systems. The system that assessed only the presence of interstitial shadowing, cystic elements and hyperinflation had the highest specificity in identifying oxygen dependency beyond 36 weeks PCA and had the highest area under the respective receiver operator characteristic curve. In conclusion, the majority of very immature infants have an abnormal chest radiograph appearance at 36 weeks PCA. The appearance can, however, be meaningfully scored by evaluating only three abnormalities.
0007-1285
366-369
Greenough, A.
8008d870-d219-4ebd-921b-c61d90573b98
Dimitriou, G.
f2a934e1-8d5f-4061-81a9-5c8a991501be
Johnson, A.H.
43233bba-7496-40fc-b2be-19b6cfc2d1c1
Calvert, S.
db77fcc0-ff18-4116-921f-a50e34503e9f
Peacock, J.L.
8362b3b1-458f-4152-936f-344ca1c7e0ba
Karani, J.
886420d8-e1fb-44a1-a949-43519c270cef
Greenough, A.
8008d870-d219-4ebd-921b-c61d90573b98
Dimitriou, G.
f2a934e1-8d5f-4061-81a9-5c8a991501be
Johnson, A.H.
43233bba-7496-40fc-b2be-19b6cfc2d1c1
Calvert, S.
db77fcc0-ff18-4116-921f-a50e34503e9f
Peacock, J.L.
8362b3b1-458f-4152-936f-344ca1c7e0ba
Karani, J.
886420d8-e1fb-44a1-a949-43519c270cef

Greenough, A., Dimitriou, G., Johnson, A.H., Calvert, S., Peacock, J.L. and Karani, J. (2000) The Chest radiograph appearences of very premature infants at 36 weeks post- conceptional age. British Journal of Radiology, 73 (868), 366-369.

Record type: Article

Abstract

The chest radiograph of very premature infants at 36 weeks post-conceptional age (PCA) was evaluated with regard to the degree of hyperinflation and cardiomegaly, and the presence of fibrosis/interstitial shadowing, cystic elements, air bronchograms and opacification. The evolution of abnormalities was assessed by comparing the radiograph appearance at 36 weeks PCA with that at 28 days post-natal age (PNA). Three scoring systems were used to determine how any abnormalities present could be best quantified to reflect disease severity as determined by chronic dependency upon supplementary oxygen status. Chest radiographs at 36 weeks PCA from 60 infants (median gestational age 26 weeks (range 24-28)) were studied. 47 infants also had radiographs at 28 days PNA. Only three infants had no chest radiograph abnormalities at 36 weeks PCA, although 24 infants were not dependent upon supplementary oxygen. The most common abnormalities were interstitial shadowing and hyperinflation, while cystic elements and cardiomegaly were rare. The radiographic appearance had deteriorated from 28 days PNA to 36 weeks PCA (p < 0.05); more infants at 36 weeks PCA were hyperinflated (p < 0.01). The chest radiograph appearances of infants who were dependent upon supplementary oxygen scored higher than those who were not (p < 0.01) using all three scoring systems. The system that assessed only the presence of interstitial shadowing, cystic elements and hyperinflation had the highest specificity in identifying oxygen dependency beyond 36 weeks PCA and had the highest area under the respective receiver operator characteristic curve. In conclusion, the majority of very immature infants have an abnormal chest radiograph appearance at 36 weeks PCA. The appearance can, however, be meaningfully scored by evaluating only three abnormalities.

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Published date: 2000

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Local EPrints ID: 72784
URI: https://eprints.soton.ac.uk/id/eprint/72784
ISSN: 0007-1285
PURE UUID: 7d92d29e-6737-42d3-ba22-bd760da864f5

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Date deposited: 24 Feb 2010
Last modified: 18 Jul 2017 23:53

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