Noninvasive fetal electrocardiography following
intermittent umbilical cord occlusion
in the preterm ovine fetus
Noninvasive fetal electrocardiography following
intermittent umbilical cord occlusion
in the preterm ovine fetus
Objective: to investigate whether a noninvasive fetal electrocardiography (fECG) system can identify cardiovascular responses to fetal hypoxaemia and validate the results using standard invasive fECG monitoring techniques.
Design: prospective cohort study.
Setting: biological research facilities at The University of Southampton.
Population or Sample: late gestation ovine fetuses; n = 5.
Methods: five fetal lambs underwent implantation of vascular catheters, umbilical cord occluder and invasive ECG chest electrodes under general anaesthesia (3% halothane/O2) at 119 days of gestation (term ?147 days of gestation). After 5 days of recovery blood pressure, blood gases, glucose and pH were monitored. At 124 and 125 days of gestation following a 10-minute baseline period a 90-second cord occlusion was applied. Noninvasive fetal ECG was recorded from maternal transabdominal electrodes using advanced signal-processing techniques, concurrently with invasive fECG recordings.
Main outcome measures: comparison of T:QRS ratios of the ECG waveform from noninvasive and invasive fECG monitoring systems.
Results: our fECG monitoring system is able to demonstrate changes in waveforms during periods of hypoxaemia similar to those obtained invasively, which could indicate fetal distress.
Conclusions: these findings may indicate a future use for noninvasive electrocardiography during human fetal monitoring both before and during labour in term and preterm pregnancies.
cord occlusion, electrocardiography, fetus
438-444
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Thomas, M.
f5239f6a-49f5-4645-9f1c-37ae8fbcd0d5
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Paterson-Brown, S.
bd23fd13-f807-48da-9e15-9a76f94eea9e
Gardiner, H.M.
e4167ce0-dc23-4479-9bdf-6a51a2ee6f23
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
March 2010
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Thomas, M.
f5239f6a-49f5-4645-9f1c-37ae8fbcd0d5
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Paterson-Brown, S.
bd23fd13-f807-48da-9e15-9a76f94eea9e
Gardiner, H.M.
e4167ce0-dc23-4479-9bdf-6a51a2ee6f23
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Cleal, J.K., Thomas, M., Hanson, M.A., Paterson-Brown, S., Gardiner, H.M. and Green, L.R.
(2010)
Noninvasive fetal electrocardiography following
intermittent umbilical cord occlusion
in the preterm ovine fetus.
BJOG: An International Journal of Obstetrics & Gynaecology, 117 (4), .
(doi:10.1111/j.1471-0528.2009.02471.x).
Abstract
Objective: to investigate whether a noninvasive fetal electrocardiography (fECG) system can identify cardiovascular responses to fetal hypoxaemia and validate the results using standard invasive fECG monitoring techniques.
Design: prospective cohort study.
Setting: biological research facilities at The University of Southampton.
Population or Sample: late gestation ovine fetuses; n = 5.
Methods: five fetal lambs underwent implantation of vascular catheters, umbilical cord occluder and invasive ECG chest electrodes under general anaesthesia (3% halothane/O2) at 119 days of gestation (term ?147 days of gestation). After 5 days of recovery blood pressure, blood gases, glucose and pH were monitored. At 124 and 125 days of gestation following a 10-minute baseline period a 90-second cord occlusion was applied. Noninvasive fetal ECG was recorded from maternal transabdominal electrodes using advanced signal-processing techniques, concurrently with invasive fECG recordings.
Main outcome measures: comparison of T:QRS ratios of the ECG waveform from noninvasive and invasive fECG monitoring systems.
Results: our fECG monitoring system is able to demonstrate changes in waveforms during periods of hypoxaemia similar to those obtained invasively, which could indicate fetal distress.
Conclusions: these findings may indicate a future use for noninvasive electrocardiography during human fetal monitoring both before and during labour in term and preterm pregnancies.
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More information
Published date: March 2010
Keywords:
cord occlusion, electrocardiography, fetus
Identifiers
Local EPrints ID: 72818
URI: http://eprints.soton.ac.uk/id/eprint/72818
ISSN: 1470-0328
PURE UUID: b7eb3e1c-1084-4a6f-8220-710652fad109
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Date deposited: 23 Feb 2010
Last modified: 14 Mar 2024 02:46
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Contributors
Author:
M. Thomas
Author:
S. Paterson-Brown
Author:
H.M. Gardiner
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