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Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus

Record type: Article

Objective: to investigate whether a noninvasive fetal electrocardiography (fECG) system can identify cardiovascular responses to fetal hypoxaemia and validate the results using standard invasive fECG monitoring techniques.
Design: prospective cohort study.
Setting: biological research facilities at The University of Southampton.
Population or Sample: late gestation ovine fetuses; n = 5.
Methods: five fetal lambs underwent implantation of vascular catheters, umbilical cord occluder and invasive ECG chest electrodes under general anaesthesia (3% halothane/O2) at 119 days of gestation (term ?147 days of gestation). After 5 days of recovery blood pressure, blood gases, glucose and pH were monitored. At 124 and 125 days of gestation following a 10-minute baseline period a 90-second cord occlusion was applied. Noninvasive fetal ECG was recorded from maternal transabdominal electrodes using advanced signal-processing techniques, concurrently with invasive fECG recordings.
Main outcome measures: comparison of T:QRS ratios of the ECG waveform from noninvasive and invasive fECG monitoring systems.
Results: our fECG monitoring system is able to demonstrate changes in waveforms during periods of hypoxaemia similar to those obtained invasively, which could indicate fetal distress.
Conclusions: these findings may indicate a future use for noninvasive electrocardiography during human fetal monitoring both before and during labour in term and preterm pregnancies

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Citation

Cleal, J.K., Thomas, M., Hanson, M.A., Paterson-Brown, S., Gardiner, H.M. and Green, L.R. (2010) Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus BJOG: An International Journal of Obstetrics & Gynaecology, 117, (4), pp. 438-444. (doi:10.1111/j.1471-0528.2009.02471.x).

More information

Published date: March 2010

Identifiers

Local EPrints ID: 72818
URI: http://eprints.soton.ac.uk/id/eprint/72818
ISSN: 1470-0328
PURE UUID: b7eb3e1c-1084-4a6f-8220-710652fad109
ORCID for L.R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 23 Feb 2010
Last modified: 18 Jul 2017 23:52

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Contributors

Author: J.K. Cleal
Author: M. Thomas
Author: M.A. Hanson
Author: S. Paterson-Brown
Author: H.M. Gardiner
Author: L.R. Green ORCID iD

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