Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of hepatic dysfunction encountered in general practice. A large proportion of individuals with type 2 diabetes and the metabolic syndrome develop NAFLD. NAFLD is associated with severe insulin resistance and increased risk of cardiovascular disease and can progress to non-alcoholic steato-hepatitis, liver cirrhosis and cancer. Currently the only known effective treatments for NAFLD are lifestyle changes including stable weight loss and a diet low in calories. General practitioners will increasingly play a key role in dealing with this evolving but serious epidemic of NAFLD and associated metabolic complications. However, success will depend on the appropriate systems and mechanisms being in place in primary care and the proper motivation, support and education of the patient. This review provides the primary care physician with: (a) a step-by step guide of how to identify NAFLD, (b) information to exclude common other causes of liver fat accumulation and (c) additional insight into relationships between NAFLD and other conditions such as obesity, cardiovascular disease and type 2 diabetes.
non-alcoholic fatty liver disease (NAFLD), cardiovascular diseases (CVDs), metabolic syndrome
129-137
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Abu, Emmanuel O.
de3b0836-486c-454d-be68-8e6bc2b98ba2
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
October 2010
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Abu, Emmanuel O.
de3b0836-486c-454d-be68-8e6bc2b98ba2
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, Mohamed H., Abu, Emmanuel O. and Byrne, Christopher D.
(2010)
Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
Primary Care Diabetes, 4 (3), .
(doi:10.1016/j.pcd.2010.02.004).
(PMID:20299294)
Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of hepatic dysfunction encountered in general practice. A large proportion of individuals with type 2 diabetes and the metabolic syndrome develop NAFLD. NAFLD is associated with severe insulin resistance and increased risk of cardiovascular disease and can progress to non-alcoholic steato-hepatitis, liver cirrhosis and cancer. Currently the only known effective treatments for NAFLD are lifestyle changes including stable weight loss and a diet low in calories. General practitioners will increasingly play a key role in dealing with this evolving but serious epidemic of NAFLD and associated metabolic complications. However, success will depend on the appropriate systems and mechanisms being in place in primary care and the proper motivation, support and education of the patient. This review provides the primary care physician with: (a) a step-by step guide of how to identify NAFLD, (b) information to exclude common other causes of liver fat accumulation and (c) additional insight into relationships between NAFLD and other conditions such as obesity, cardiovascular disease and type 2 diabetes.
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Published date: October 2010
Keywords:
non-alcoholic fatty liver disease (NAFLD), cardiovascular diseases (CVDs), metabolic syndrome
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Local EPrints ID: 72819
URI: http://eprints.soton.ac.uk/id/eprint/72819
ISSN: 1751-9918
PURE UUID: 73945f73-201f-41aa-aa7a-77036fb2f387
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Date deposited: 23 Feb 2010
Last modified: 14 Mar 2024 02:43
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Author:
Mohamed H. Ahmed
Author:
Emmanuel O. Abu
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