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Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?

Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of hepatic dysfunction encountered in general practice. A large proportion of individuals with type 2 diabetes and the metabolic syndrome develop NAFLD. NAFLD is associated with severe insulin resistance and increased risk of cardiovascular disease and can progress to non-alcoholic steato-hepatitis, liver cirrhosis and cancer. Currently the only known effective treatments for NAFLD are lifestyle changes including stable weight loss and a diet low in calories. General practitioners will increasingly play a key role in dealing with this evolving but serious epidemic of NAFLD and associated metabolic complications. However, success will depend on the appropriate systems and mechanisms being in place in primary care and the proper motivation, support and education of the patient. This review provides the primary care physician with: (a) a step-by step guide of how to identify NAFLD, (b) information to exclude common other causes of liver fat accumulation and (c) additional insight into relationships between NAFLD and other conditions such as obesity, cardiovascular disease and type 2 diabetes.
non-alcoholic fatty liver disease (NAFLD), cardiovascular diseases (CVDs), metabolic syndrome
1751-9918
129-137
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Abu, Emmanuel O.
de3b0836-486c-454d-be68-8e6bc2b98ba2
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Abu, Emmanuel O.
de3b0836-486c-454d-be68-8e6bc2b98ba2
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Ahmed, Mohamed H., Abu, Emmanuel O. and Byrne, Christopher D. (2010) Non alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities? Primary Care Diabetes, 4 (3), 129-137. (doi:10.1016/j.pcd.2010.02.004). (PMID:20299294)

Record type: Article

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of hepatic dysfunction encountered in general practice. A large proportion of individuals with type 2 diabetes and the metabolic syndrome develop NAFLD. NAFLD is associated with severe insulin resistance and increased risk of cardiovascular disease and can progress to non-alcoholic steato-hepatitis, liver cirrhosis and cancer. Currently the only known effective treatments for NAFLD are lifestyle changes including stable weight loss and a diet low in calories. General practitioners will increasingly play a key role in dealing with this evolving but serious epidemic of NAFLD and associated metabolic complications. However, success will depend on the appropriate systems and mechanisms being in place in primary care and the proper motivation, support and education of the patient. This review provides the primary care physician with: (a) a step-by step guide of how to identify NAFLD, (b) information to exclude common other causes of liver fat accumulation and (c) additional insight into relationships between NAFLD and other conditions such as obesity, cardiovascular disease and type 2 diabetes.

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More information

Published date: October 2010
Keywords: non-alcoholic fatty liver disease (NAFLD), cardiovascular diseases (CVDs), metabolic syndrome

Identifiers

Local EPrints ID: 72819
URI: https://eprints.soton.ac.uk/id/eprint/72819
ISSN: 1751-9918
PURE UUID: 73945f73-201f-41aa-aa7a-77036fb2f387
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 23 Feb 2010
Last modified: 06 Jun 2018 12:53

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