Nott, M.R., Clemson, C.J. and Peacock, J.L.
Onset time of topical analgesia with EMLA 5%: no reduction with glyceryl trinitrate
European Journal of Anaesthesiology, 13, (1), .
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Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P = 0.01).
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