Gp-340/DMBT1 in mucosal innate immunity
Gp-340/DMBT1 in mucosal innate immunity
Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1(gp340)) and salivary agglutinin (DMBT1(SAG)). DMBT1(gp340) is secreted into broncho-alveolar surface lining fluid whereas DMBT(SAG) is present in the saliva. The two molecules were shown to be identical and both interact with and agglutinate several Gram-negative and Gram-positive bacteria including Streptococcus mutans, a bacterium responsible for caries in the oral cavity. DMBT1(gp340) interacts with surfactant proteins A and D (SP-D). DMBT1(gp340) and SP-D can individually and together interact and agglutinate influenza A virus. DMBT1(gp340) also binds to HIV-1 and facilitates transcytosis of the virus into epithelial cells. DMBT1 binds to a variety of other host proteins, including serum and secretory IgA, C1q, lactoferrin, MUC5B and trefoil factor 2 (TFF2), all molecules with involvement in innate immunity and/or wound-healing processes. Recent generation of Dmbt1-deficient mice has provided the research field of DMBT1 with a model that allows research to progress from in vitro studies to in vivo functional studies of the multifunctional proteins encoded by the DMBT1 gene.
160-167
Madsen, J.
b5d8ae35-00ac-4d19-930e-d8ddec497359
Mollenhauer, J.
609af070-89a7-4250-8c5c-0ace010e27e6
Holmskov, U.
a5c73f03-fa11-4f50-baa1-1d66d6151b8f
Madsen, J.
b5d8ae35-00ac-4d19-930e-d8ddec497359
Mollenhauer, J.
609af070-89a7-4250-8c5c-0ace010e27e6
Holmskov, U.
a5c73f03-fa11-4f50-baa1-1d66d6151b8f
Madsen, J., Mollenhauer, J. and Holmskov, U.
(2010)
Gp-340/DMBT1 in mucosal innate immunity.
Innate Immunity, 16 (3), .
(PMID:PMID: 20418254)
Abstract
Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1(gp340)) and salivary agglutinin (DMBT1(SAG)). DMBT1(gp340) is secreted into broncho-alveolar surface lining fluid whereas DMBT(SAG) is present in the saliva. The two molecules were shown to be identical and both interact with and agglutinate several Gram-negative and Gram-positive bacteria including Streptococcus mutans, a bacterium responsible for caries in the oral cavity. DMBT1(gp340) interacts with surfactant proteins A and D (SP-D). DMBT1(gp340) and SP-D can individually and together interact and agglutinate influenza A virus. DMBT1(gp340) also binds to HIV-1 and facilitates transcytosis of the virus into epithelial cells. DMBT1 binds to a variety of other host proteins, including serum and secretory IgA, C1q, lactoferrin, MUC5B and trefoil factor 2 (TFF2), all molecules with involvement in innate immunity and/or wound-healing processes. Recent generation of Dmbt1-deficient mice has provided the research field of DMBT1 with a model that allows research to progress from in vitro studies to in vivo functional studies of the multifunctional proteins encoded by the DMBT1 gene.
This record has no associated files available for download.
More information
Submitted date: 2010
Accepted/In Press date: 2010
e-pub ahead of print date: 23 April 2010
Identifiers
Local EPrints ID: 72851
URI: http://eprints.soton.ac.uk/id/eprint/72851
ISSN: 1753-4267
PURE UUID: f52f47be-9dc6-456c-a6e2-6622907d71fb
Catalogue record
Date deposited: 24 Feb 2010
Last modified: 23 Jul 2022 01:58
Export record
Contributors
Author:
J. Madsen
Author:
J. Mollenhauer
Author:
U. Holmskov
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics