Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering
Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering
Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone regeneration. Tissue engineering seeks to harness the regenerative capacity innate to bone for the replacement of tissue lost or damaged through a broad range of conditions associated with an increasingly aged population. The strategy entails ex vivo expansion of multipotential populations followed by delivery to the site of damage on dynamically durable-biodegradable three-dimensional structures which provide the requisite extracellular microenvironment for stem cell driven tissue development. This review will examine bone stem cell biology, and current advances in skeletal tissue engineering through the enhancement and marrying of biologically informed and clinically relevant strategies.
124-31
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
May 2008
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I. and Oreffo, Richard O.C.
(2008)
Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering.
Archives of Biochemistry and Biophysics, 473 (2), .
(doi:10.1016/j.abb.2008.03.024).
(PMID:18396145)
Abstract
Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone regeneration. Tissue engineering seeks to harness the regenerative capacity innate to bone for the replacement of tissue lost or damaged through a broad range of conditions associated with an increasingly aged population. The strategy entails ex vivo expansion of multipotential populations followed by delivery to the site of damage on dynamically durable-biodegradable three-dimensional structures which provide the requisite extracellular microenvironment for stem cell driven tissue development. This review will examine bone stem cell biology, and current advances in skeletal tissue engineering through the enhancement and marrying of biologically informed and clinically relevant strategies.
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Published date: May 2008
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Local EPrints ID: 72898
URI: http://eprints.soton.ac.uk/id/eprint/72898
ISSN: 0003-9861
PURE UUID: c7eede28-889d-42fd-bb08-0497304f6ed4
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Date deposited: 24 Feb 2010
Last modified: 14 Mar 2024 02:53
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