Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study
Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study
Summary: this case–control study showed that current use of conventional antipsychotics, but not atypical antipsychotics, seems to be associated with an increased risk of a hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. Furthermore, no evidence for a dose effect was found.
Introduction: the aim of this study was to assess the risk of hip/femur fracture associated with antipsychotic use, with particular reference to any difference in risk with conventional versus atypical antipsychotics, dose, and pharmacological properties.
Methods: a case–control study was conducted using data from the PHARMO Record Linkage System among individuals aged 18 years and older between 1991 and 2002. Cases had a record of a hip or femur fracture, while controls had no evidence of ever having sustained any fracture.
Results: most cases were elderly (77.6% aged ?70 years). We found an increased risk for hip/femur fracture associated with the use of antipsychotic drugs. The risk for current users (ORadj 1.68 [1.43, 1.99]) was significantly greater than with past use (ORadj 1.33 [1.14, 1.56]; p?=?0.036). Current use of conventional antipsychotics (ORadj 1.76 [1.48, 2.08]) but not atypical antipsychotics (ORadj 0.83 [0.42, 1.65]) was associated with an increased risk. We did not find evidence for a dose effect.
Conclusion: the use of conventional, but not atypical antipsychotics, seems to be associated with an increased risk of hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. However, the numbers of atypical antipsychotic users were small, and therefore this observation needs further attention in other study populations
antipsychotics, bone density, fracture, osteoporosis, risk factors
1499-1506
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Egberts, A.C.G.
eb765fde-f548-4c1a-8683-5480573617d5
Leufkens, H.G.M.
04854167-bea6-4508-a8e2-aeb920a2d6b1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
September 2009
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Egberts, A.C.G.
eb765fde-f548-4c1a-8683-5480573617d5
Leufkens, H.G.M.
04854167-bea6-4508-a8e2-aeb920a2d6b1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S., van Staa, T.P., Egberts, A.C.G., Leufkens, H.G.M., Cooper, C. and de Vries, F.
(2009)
Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study.
Osteoporosis International, 20 (9), .
(doi:10.1007/s00198-008-0826-5).
Abstract
Summary: this case–control study showed that current use of conventional antipsychotics, but not atypical antipsychotics, seems to be associated with an increased risk of a hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. Furthermore, no evidence for a dose effect was found.
Introduction: the aim of this study was to assess the risk of hip/femur fracture associated with antipsychotic use, with particular reference to any difference in risk with conventional versus atypical antipsychotics, dose, and pharmacological properties.
Methods: a case–control study was conducted using data from the PHARMO Record Linkage System among individuals aged 18 years and older between 1991 and 2002. Cases had a record of a hip or femur fracture, while controls had no evidence of ever having sustained any fracture.
Results: most cases were elderly (77.6% aged ?70 years). We found an increased risk for hip/femur fracture associated with the use of antipsychotic drugs. The risk for current users (ORadj 1.68 [1.43, 1.99]) was significantly greater than with past use (ORadj 1.33 [1.14, 1.56]; p?=?0.036). Current use of conventional antipsychotics (ORadj 1.76 [1.48, 2.08]) but not atypical antipsychotics (ORadj 0.83 [0.42, 1.65]) was associated with an increased risk. We did not find evidence for a dose effect.
Conclusion: the use of conventional, but not atypical antipsychotics, seems to be associated with an increased risk of hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. However, the numbers of atypical antipsychotic users were small, and therefore this observation needs further attention in other study populations
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Published date: September 2009
Keywords:
antipsychotics, bone density, fracture, osteoporosis, risk factors
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Local EPrints ID: 72904
URI: http://eprints.soton.ac.uk/id/eprint/72904
ISSN: 0937-941X
PURE UUID: 9bbb9b02-1cc7-492d-be4e-cb6f2ba224ba
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Date deposited: 24 Feb 2010
Last modified: 18 Mar 2024 02:44
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Author:
S. Pouwels
Author:
T.P. van Staa
Author:
A.C.G. Egberts
Author:
H.G.M. Leufkens
Author:
F. de Vries
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