Whistance, R.N., Conroy, T., Chie, W., Costantini, A., Sezer, O., Koller, M., Johnson, C.D., Pilkington, S.A., Arraras, J., Ben-Josef, E., Pullyblank, A.M., Fayers, P. and Blazeby, J.M.
Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer
European Journal of Cancer, 45, (17), . (doi:10.1016/j.ejca.2009.08.014).
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This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module
for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were
assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time
in stable health.
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