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Aggressive multi-visceral pancreatic resections for locally advanced neuroendocrine tumours. Is it worth it?

Record type: Article

Context
Traditional surgical principles state that pancreatic resection should not be contemplated when malignancies arise in the pancreas and involve other organs. While this is logic for ductal adenocarcinoma and other tumours with aggressive biological behavior; for even large neuroendocrine tumours, aggressive multivisceral resection may achieve useful palliation and excellent survival.
Design
Case records were retrospectively analyzed.
Patients and interventions
Twelve consecutive patients (7 males, 5 females; median age 57 years, range: 37-79 years) underwent multi-visceral en bloc resections for neuroendocrine tumour arising in the pancreas between 1994 and 2008.
Results
Three patients underwent pancreaticoduodenectomy; 9 patients had left sided pancreatic resections for neuroendocrine tumour of median diameter 9.5 cm ( 5-25 cm). They had a median of 3 (range: 1-4) additional organs resected. There were no post-operative deaths or late mortality with median follow up of 24 months. Five patients experienced a complication (major in 3 patients). Median disease free survival was not attained and 3 patients experienced recurrent disease mostly in the liver and may be candidates for further resection.
Conclusion
Aggressive multi-visceral resection for locally advanced neuroendocrine tumour involving the pancreas is technically feasible and in selected patients can be achieved with low mortality and acceptable morbidity, offering good disease free and overall survival. However this complex surgery should be only performed in specialist centers.

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Citation

Abu Hilal, Mohammed, McPhail, Mark J.W., Zeidan, Bashar A., Jones, Ceri E., Johnson, Colin D. and Pearce, Neil W. (2009) Aggressive multi-visceral pancreatic resections for locally advanced neuroendocrine tumours. Is it worth it? JOP: Journal of the Pancreas, 10, (3), pp. 276-279.

More information

Published date: 18 May 2009
Keywords: neuroendocrine tumors, pancreas, pancreatic neoplasms

Identifiers

Local EPrints ID: 73004
URI: http://eprints.soton.ac.uk/id/eprint/73004
ISSN: 1590-8577
PURE UUID: dc2dfc7f-0355-4358-aeb1-306f9ee9e269

Catalogue record

Date deposited: 26 Feb 2010
Last modified: 18 Jul 2017 23:51

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Contributors

Author: Mohammed Abu Hilal
Author: Mark J.W. McPhail
Author: Bashar A. Zeidan
Author: Ceri E. Jones
Author: Neil W. Pearce

University divisions


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