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Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study

Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study
Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study
Purpose Cancer cachexia impacts on treatment options, quality of life and survival. New treatments are emerging but need to be assessed using outcomes which patients find meaningful. One approach is the measurement of physical activity levels by small lightweight monitors, but experience is limited in cancer patients.
Materials and methods This study formally assessed the acceptability of wearing an ActivPAL™ monitor for 1 week using compliance based on analysis of movement data. The optimal period of monitoring was explored by comparing mean values of daily step count and energy expenditure (EE) for 2 or 4 and 6 days of monitoring. The relationships between step count, stepping EE and non-stepping EE were also explored.
Results Sixty patients (mean age 68 years; Eastern Cooperative Oncology Group performance status 0–2) with lung or upper gastrointestinal cancer took part. All but one found that the monitor acceptable and mean [95% CI] compliance was 98% [94–100%]. Median daily step counts and EE scores over 2 or 4 days were significantly higher than those from 6 days (p ? 0.01). Step count was strongly related to stepping and non-stepping EE (r?= ?0.911, p?<?0.01).
Conclusions The ActivPAL™ is acceptable to patients with outcomes obtained over 6 days recommended for use in future studies.
0941-4355
Maddocks, Matthew
33311e9a-383e-4824-8fed-524778230b1a
Byrne, Anthony
b3f1c924-7ea7-49a8-bcd1-3e83609362e3
Johnson, Colin D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Wilson, Richard H.
d9c481a6-7960-45c7-ba93-8f9542bdcecc
Fearon, Kenneth C.H.
021154b0-9dc2-4bf0-ade9-891e2fe9a8fc
Wilcock, Andrew
724d6c43-6d18-4c04-a072-5b56ccb13656
Maddocks, Matthew
33311e9a-383e-4824-8fed-524778230b1a
Byrne, Anthony
b3f1c924-7ea7-49a8-bcd1-3e83609362e3
Johnson, Colin D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Wilson, Richard H.
d9c481a6-7960-45c7-ba93-8f9542bdcecc
Fearon, Kenneth C.H.
021154b0-9dc2-4bf0-ade9-891e2fe9a8fc
Wilcock, Andrew
724d6c43-6d18-4c04-a072-5b56ccb13656

Maddocks, Matthew, Byrne, Anthony, Johnson, Colin D., Wilson, Richard H., Fearon, Kenneth C.H. and Wilcock, Andrew (2009) Physical activity level as an outcome measure for use in cancer cachexia trials: a feasibility study. Supportive Care in Cancer. (doi:10.1007/s00520-009-0776-2).

Record type: Article

Abstract

Purpose Cancer cachexia impacts on treatment options, quality of life and survival. New treatments are emerging but need to be assessed using outcomes which patients find meaningful. One approach is the measurement of physical activity levels by small lightweight monitors, but experience is limited in cancer patients.
Materials and methods This study formally assessed the acceptability of wearing an ActivPAL™ monitor for 1 week using compliance based on analysis of movement data. The optimal period of monitoring was explored by comparing mean values of daily step count and energy expenditure (EE) for 2 or 4 and 6 days of monitoring. The relationships between step count, stepping EE and non-stepping EE were also explored.
Results Sixty patients (mean age 68 years; Eastern Cooperative Oncology Group performance status 0–2) with lung or upper gastrointestinal cancer took part. All but one found that the monitor acceptable and mean [95% CI] compliance was 98% [94–100%]. Median daily step counts and EE scores over 2 or 4 days were significantly higher than those from 6 days (p ? 0.01). Step count was strongly related to stepping and non-stepping EE (r?= ?0.911, p?<?0.01).
Conclusions The ActivPAL™ is acceptable to patients with outcomes obtained over 6 days recommended for use in future studies.

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Published date: 2 December 2009

Identifiers

Local EPrints ID: 73014
URI: http://eprints.soton.ac.uk/id/eprint/73014
ISSN: 0941-4355
PURE UUID: 790f53ce-d3a3-4351-b283-7c262fde20c1

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Date deposited: 01 Mar 2010
Last modified: 13 Mar 2024 21:50

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Contributors

Author: Matthew Maddocks
Author: Anthony Byrne
Author: Richard H. Wilson
Author: Kenneth C.H. Fearon
Author: Andrew Wilcock

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