Prostasomes, angiogenesis, and tissue factor
Prostasomes, angiogenesis, and tissue factor
Prostasomes are membrane-bound secretory vesicles produced by prostatic epithelial cells. They are known to carry many proteins, including tissue factor, and have membranes unusually rich in cholesterol and sphingomyelin. Prostasomes have well-documented effects on fertility, promoting sperm motility, stabilizing the acrosome reaction, and facilitating immunosuppression. This article reviews the evidence of the effects of prostasomes on in vitro angiogenesis assays, and the mechanism by which these effects occur. Seminal prostasomes seem to inhibit angiogenesis, whereas the equivalent particles released by malignant prostate cells promote angiogenesis. In both cases, the effects seem preserved after heat treatment to denature the protein content, suggesting an important role for lipid transfer, in particular, transfer of sphingomyelin
75-79
Delves, George H.
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Stewart, Alistair B.
f4590e6c-407d-42bb-8437-564f20413df8
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
2007
Delves, George H.
e24020b5-6bf1-49b5-96ea-860b7886d8fa
Stewart, Alistair B.
f4590e6c-407d-42bb-8437-564f20413df8
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Delves, George H., Stewart, Alistair B., Cooper, Alan J. and Lwaleed, B.A.
(2007)
Prostasomes, angiogenesis, and tissue factor.
Seminars in Thrombosis and Hemostasis, 33, .
Abstract
Prostasomes are membrane-bound secretory vesicles produced by prostatic epithelial cells. They are known to carry many proteins, including tissue factor, and have membranes unusually rich in cholesterol and sphingomyelin. Prostasomes have well-documented effects on fertility, promoting sperm motility, stabilizing the acrosome reaction, and facilitating immunosuppression. This article reviews the evidence of the effects of prostasomes on in vitro angiogenesis assays, and the mechanism by which these effects occur. Seminal prostasomes seem to inhibit angiogenesis, whereas the equivalent particles released by malignant prostate cells promote angiogenesis. In both cases, the effects seem preserved after heat treatment to denature the protein content, suggesting an important role for lipid transfer, in particular, transfer of sphingomyelin
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Published date: 2007
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Local EPrints ID: 73022
URI: http://eprints.soton.ac.uk/id/eprint/73022
ISSN: 0094-6176
PURE UUID: cfb1304a-6285-44d7-97ca-f6485b244784
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Date deposited: 04 Mar 2010
Last modified: 06 Aug 2024 01:39
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Author:
George H. Delves
Author:
Alistair B. Stewart
Author:
Alan J. Cooper
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