Breakdown in epithelial barrier function in
patients with asthma: identification of novel therapeutic approaches
Breakdown in epithelial barrier function in
patients with asthma: identification of novel therapeutic approaches
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure
asthma, epithelium, tight junction, innate immunity, permeability, allergen, virus
23-34
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Collins, Jane E.
be0e66f1-3036-47fa-9d7e-914c48710ba4
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
July 2009
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Collins, Jane E.
be0e66f1-3036-47fa-9d7e-914c48710ba4
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Swindle, Emily J., Collins, Jane E. and Davies, Donna E.
(2009)
Breakdown in epithelial barrier function in
patients with asthma: identification of novel therapeutic approaches.
Journal of Allergy and Clinical Immunology, 124 (1), .
(doi:10.1016/j.jaci.2009.05.037).
Abstract
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure
This record has no associated files available for download.
More information
Published date: July 2009
Keywords:
asthma, epithelium, tight junction, innate immunity, permeability, allergen, virus
Organisations:
Infection Inflammation & Immunity
Identifiers
Local EPrints ID: 73029
URI: http://eprints.soton.ac.uk/id/eprint/73029
ISSN: 0091-6749
PURE UUID: 58dae201-f64c-49eb-adf5-c7085fbe7f1f
Catalogue record
Date deposited: 26 Feb 2010
Last modified: 14 Mar 2024 02:55
Export record
Altmetrics
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics