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Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches

Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches
Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure
asthma, epithelium, tight junction, innate immunity, permeability, allergen, virus
0091-6749
23-34
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Collins, Jane E.
be0e66f1-3036-47fa-9d7e-914c48710ba4
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Collins, Jane E.
be0e66f1-3036-47fa-9d7e-914c48710ba4
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38

Swindle, Emily J., Collins, Jane E. and Davies, Donna E. (2009) Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches. Journal of Allergy and Clinical Immunology, 124 (1), 23-34. (doi:10.1016/j.jaci.2009.05.037).

Record type: Article

Abstract

The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure

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More information

Published date: July 2009
Keywords: asthma, epithelium, tight junction, innate immunity, permeability, allergen, virus
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 73029
URI: http://eprints.soton.ac.uk/id/eprint/73029
ISSN: 0091-6749
PURE UUID: 58dae201-f64c-49eb-adf5-c7085fbe7f1f
ORCID for Emily J. Swindle: ORCID iD orcid.org/0000-0003-3644-7747
ORCID for Donna E. Davies: ORCID iD orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 26 Feb 2010
Last modified: 14 Mar 2024 02:55

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