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Plasma total homocysteine (tHcy) levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus

Plasma total homocysteine (tHcy) levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus
Plasma total homocysteine (tHcy) levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus
Background: thrombotic episodes account for approximately 80% of deaths in type 2 diabetic patients. Hyperhomocysteinaemia is a well recognized independent risk factor for atherosclerosis and thromboembolism. Increased homocysteine levels may occur due to a number of factors including inherited gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T. Here, we evaluate plas- ma total homocysteine (tHcy) levels and frequency of the MTHFR C677T gene polymorphism in asymptomatic healthy volunteers and type 2 diabetic patients with hypertension but without nephropathy. We have also investigated the relationship between tHcy levels and the presence of MTHFR C677T gene polymorphism.
Methods: plasma tHcy levels and MTHFR C677T genotype were investigated in a total of 53 subjects. These included asymptomatic healthy volunteers (n = 16), patients with type 2 diabetes (n = 7), subjects with hypertension (n = 12) and patients with both type 2 diabetes and hypertension (n = 18). Renal function, serum lipids and other metabolites were also assessed.
Results: there was no significant difference in tHcy levels between the groups studied. The frequency of MTHFR C677T gene polymorphism observed was similar to that obtained for the general Brazilian population. In patients with type 2 diabetes and hypertension but without impaired renal function, we observed no meaningful correlation between increased tHcy levels and the presence of MTHFR C677T gene polymorphism.
Conclusions: type 2 diabetics who are homozygous or heterozygous for the MTHFR C677T gene polymorphism showed normal tHcy levels. Our results further suggest that diabetes without an associated adverse risk profile is not an independent correlate of increased tHcy levels
1424-8832
275-281
Soares, Anna L.
4c6d6886-28dd-4e14-bddf-ccf1748b75ad
Fernandes, Ana P.
f3e4e2c3-ef81-44a2-8c5c-b41067ad7585
Cardoso, Jarbas E.
f8abf708-89c8-4316-b889-14aa9933998d
Sousa, Marinez O.
bfe83c34-64fa-4ac8-827f-98c5b45c0f12
Lasmar, Marcelo C.
959278fb-7ee3-4643-ac48-9ae2b204a7d8
Novelli, Bethania A.
ea4bf889-7cdb-4036-9c1f-0a5d674f8c20
Lages, Gerlada F.
c79420f5-8ae6-48f4-957f-d4970c777fb9
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Vieira, Lauro M.
ae7e87cf-8dd3-4a36-87f0-6fc053562e8a
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f
Soares, Anna L.
4c6d6886-28dd-4e14-bddf-ccf1748b75ad
Fernandes, Ana P.
f3e4e2c3-ef81-44a2-8c5c-b41067ad7585
Cardoso, Jarbas E.
f8abf708-89c8-4316-b889-14aa9933998d
Sousa, Marinez O.
bfe83c34-64fa-4ac8-827f-98c5b45c0f12
Lasmar, Marcelo C.
959278fb-7ee3-4643-ac48-9ae2b204a7d8
Novelli, Bethania A.
ea4bf889-7cdb-4036-9c1f-0a5d674f8c20
Lages, Gerlada F.
c79420f5-8ae6-48f4-957f-d4970c777fb9
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Vieira, Lauro M.
ae7e87cf-8dd3-4a36-87f0-6fc053562e8a
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f

Soares, Anna L., Fernandes, Ana P., Cardoso, Jarbas E., Sousa, Marinez O., Lasmar, Marcelo C., Novelli, Bethania A., Lages, Gerlada F., Dusse, Luci M., Vieira, Lauro M., Lwaleed, Bashir A. and Carvalho, Maria G. (2008) Plasma total homocysteine (tHcy) levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus. Pathophysiology of Haemostasis and Thrombosis, 36 (5), 275-281. (doi:10.1159/000252825).

Record type: Article

Abstract

Background: thrombotic episodes account for approximately 80% of deaths in type 2 diabetic patients. Hyperhomocysteinaemia is a well recognized independent risk factor for atherosclerosis and thromboembolism. Increased homocysteine levels may occur due to a number of factors including inherited gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T. Here, we evaluate plas- ma total homocysteine (tHcy) levels and frequency of the MTHFR C677T gene polymorphism in asymptomatic healthy volunteers and type 2 diabetic patients with hypertension but without nephropathy. We have also investigated the relationship between tHcy levels and the presence of MTHFR C677T gene polymorphism.
Methods: plasma tHcy levels and MTHFR C677T genotype were investigated in a total of 53 subjects. These included asymptomatic healthy volunteers (n = 16), patients with type 2 diabetes (n = 7), subjects with hypertension (n = 12) and patients with both type 2 diabetes and hypertension (n = 18). Renal function, serum lipids and other metabolites were also assessed.
Results: there was no significant difference in tHcy levels between the groups studied. The frequency of MTHFR C677T gene polymorphism observed was similar to that obtained for the general Brazilian population. In patients with type 2 diabetes and hypertension but without impaired renal function, we observed no meaningful correlation between increased tHcy levels and the presence of MTHFR C677T gene polymorphism.
Conclusions: type 2 diabetics who are homozygous or heterozygous for the MTHFR C677T gene polymorphism showed normal tHcy levels. Our results further suggest that diabetes without an associated adverse risk profile is not an independent correlate of increased tHcy levels

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Published date: December 2008

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Local EPrints ID: 73037
URI: https://eprints.soton.ac.uk/id/eprint/73037
ISSN: 1424-8832
PURE UUID: 3253a532-41be-490e-a8c7-d3e3b148e9bf

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Date deposited: 26 Feb 2010
Last modified: 19 Jul 2019 23:41

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Contributors

Author: Anna L. Soares
Author: Ana P. Fernandes
Author: Jarbas E. Cardoso
Author: Marinez O. Sousa
Author: Marcelo C. Lasmar
Author: Bethania A. Novelli
Author: Gerlada F. Lages
Author: Luci M. Dusse
Author: Lauro M. Vieira
Author: Maria G. Carvalho

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