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Anti-prostasome antibodies are not an appropriate prognostic marker for prostate cancer

Anti-prostasome antibodies are not an appropriate prognostic marker for prostate cancer
Anti-prostasome antibodies are not an appropriate prognostic marker for prostate cancer
Objective
Antiprostasome antibodies (APAs) have been identified in serum of patients with prostate cancer and have been proposed as a new marker for metastatic disease. This study reassesses the role of APAs as a prognostic indicator for prostate cancer.
Material and methods
Serum samples from healthy controls (n7) and patients with prostate cancer (n22) were assayed for APAs using an enzyme-linked immunosorbent assay.
Results
APAs in varying amounts were present in healthy individuals as well as in men with prostate cancer. Higher levels were inversely and significantly associated with prostatespecific antigen (PSA). No significant relationships were noted between APA levels and other parameters such as age, time since diagnosis, metastatic status, Gleason histological score and hormonal treatment.
Conclusions
The presence of serum APA is unlikely to be a strong prognostic indictor for prostate cancer on an individual basis as false positives will occur. However, such immune reactions which may be associated with PSA in cancer patients are in any case of interest in both the biology of prostate cancer and male fertility. The source of prostasomal antigen may be of critical importance to the outcome of the assay. However, immune reactions to prostasomes may be of considerable interest and warrant continued investigation.
antiprostasome antibodies, prognosis, prostasomes, prostate cancer
0036-5599
104-108
Stewart, Alistair B.
f4590e6c-407d-42bb-8437-564f20413df8
Delves, George H.
e24020b5-6bf1-49b5-96ea-860b7886d8fa
Brian, Brian R.
8c5c045b-1ab1-4a61-b75e-bf3b71124089
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Stewart, Alistair B.
f4590e6c-407d-42bb-8437-564f20413df8
Delves, George H.
e24020b5-6bf1-49b5-96ea-860b7886d8fa
Brian, Brian R.
8c5c045b-1ab1-4a61-b75e-bf3b71124089
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21

Stewart, Alistair B., Delves, George H., Brian, Brian R., Cooper, Alan J. and Lwaleed, Bashir A. (2009) Anti-prostasome antibodies are not an appropriate prognostic marker for prostate cancer. Scandinavian Journal of Urology and Nephrology, 43 (2), 104-108. (doi:10.1080/00365590802502103).

Record type: Article

Abstract

Objective
Antiprostasome antibodies (APAs) have been identified in serum of patients with prostate cancer and have been proposed as a new marker for metastatic disease. This study reassesses the role of APAs as a prognostic indicator for prostate cancer.
Material and methods
Serum samples from healthy controls (n7) and patients with prostate cancer (n22) were assayed for APAs using an enzyme-linked immunosorbent assay.
Results
APAs in varying amounts were present in healthy individuals as well as in men with prostate cancer. Higher levels were inversely and significantly associated with prostatespecific antigen (PSA). No significant relationships were noted between APA levels and other parameters such as age, time since diagnosis, metastatic status, Gleason histological score and hormonal treatment.
Conclusions
The presence of serum APA is unlikely to be a strong prognostic indictor for prostate cancer on an individual basis as false positives will occur. However, such immune reactions which may be associated with PSA in cancer patients are in any case of interest in both the biology of prostate cancer and male fertility. The source of prostasomal antigen may be of critical importance to the outcome of the assay. However, immune reactions to prostasomes may be of considerable interest and warrant continued investigation.

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More information

Published date: 2009
Keywords: antiprostasome antibodies, prognosis, prostasomes, prostate cancer

Identifiers

Local EPrints ID: 73051
URI: http://eprints.soton.ac.uk/id/eprint/73051
ISSN: 0036-5599
PURE UUID: e9b4fa77-419d-4c65-b1f3-020e4b4ed659

Catalogue record

Date deposited: 26 Feb 2010
Last modified: 19 Jul 2019 23:41

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