The University of Southampton
University of Southampton Institutional Repository

Fatty liver: role of inflammation and fatty acid nutrition

Fatty liver: role of inflammation and fatty acid nutrition
Fatty liver: role of inflammation and fatty acid nutrition
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple noninvasive diagnostic tests to facilitate an estimate of prevalence but in subgroups of people such as those with type 2 diabetes, the prevalence may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and NASH is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH specifically, to develop strategies for interventions to treat this condition. The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD.
265-271
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Byrne, Christopher D. (2010) Fatty liver: role of inflammation and fatty acid nutrition. [in special issue: The Ninth Fatty Acids and Cell Signalling Meeting(FACS-09)] Prostaglandins, Leukotrienes and Essential Fatty Acids, 82 (4-6), 265-271. (doi:10.1016/j.plefa.2010.02.012).

Record type: Article

Abstract

Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple noninvasive diagnostic tests to facilitate an estimate of prevalence but in subgroups of people such as those with type 2 diabetes, the prevalence may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and NASH is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH specifically, to develop strategies for interventions to treat this condition. The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD.

PDF
Prostaglandins.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Published date: April 2010

Identifiers

Local EPrints ID: 73061
URI: https://eprints.soton.ac.uk/id/eprint/73061
PURE UUID: 2c25f309-9f2c-438a-ab45-17ef4f831be3
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 02 Mar 2010
Last modified: 06 Jun 2018 12:53

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×