Fatty liver: role of inflammation and fatty acid nutrition
Fatty liver: role of inflammation and fatty acid nutrition
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple noninvasive diagnostic tests to facilitate an estimate of prevalence but in subgroups of people such as those with type 2 diabetes, the prevalence may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and NASH is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH specifically, to develop strategies for interventions to treat this condition. The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD.
265-271
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
April 2010
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Byrne, Christopher D.
(2010)
Fatty liver: role of inflammation and fatty acid nutrition.
[in special issue: The Ninth Fatty Acids and Cell Signalling Meeting(FACS-09)]
Prostaglandins, Leukotrienes and Essential Fatty Acids, 82 (4-6), .
(doi:10.1016/j.plefa.2010.02.012).
Abstract
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple noninvasive diagnostic tests to facilitate an estimate of prevalence but in subgroups of people such as those with type 2 diabetes, the prevalence may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and NASH is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH specifically, to develop strategies for interventions to treat this condition. The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD.
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Published date: April 2010
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Local EPrints ID: 73061
URI: http://eprints.soton.ac.uk/id/eprint/73061
PURE UUID: 2c25f309-9f2c-438a-ab45-17ef4f831be3
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Date deposited: 02 Mar 2010
Last modified: 14 Mar 2024 02:43
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