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Twenty five year mortality of a community cohort with schizophrenia

Twenty five year mortality of a community cohort with schizophrenia
Twenty five year mortality of a community cohort with schizophrenia
Background: people with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s.
Aims: to measure the 25-year mortality of people with schizophrenia with particular focus on changes over time.
Method: prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia.
Results: the cohort had an all-cause standardised mortality ratio of 289 (95% CI 247–337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P = 0.053) over the course of the study.
Conclusions: people with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health
0007-1250
116-121
Brown, Steve
223fc552-5505-4271-8ec8-5c91d14cdf9c
Kim, Miranda
c2e4ad50-0a64-4da9-8335-78531d88e93d
Mitchell, Clemence
ae9f0e11-b472-4373-b84f-066318d3dd13
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Brown, Steve
223fc552-5505-4271-8ec8-5c91d14cdf9c
Kim, Miranda
c2e4ad50-0a64-4da9-8335-78531d88e93d
Mitchell, Clemence
ae9f0e11-b472-4373-b84f-066318d3dd13
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7

Brown, Steve, Kim, Miranda, Mitchell, Clemence and Inskip, Hazel (2010) Twenty five year mortality of a community cohort with schizophrenia. British Journal of Psychiatry, 196 (2), 116-121. (doi:10.1192/bjp.bp.109.067512).

Record type: Article

Abstract

Background: people with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s.
Aims: to measure the 25-year mortality of people with schizophrenia with particular focus on changes over time.
Method: prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia.
Results: the cohort had an all-cause standardised mortality ratio of 289 (95% CI 247–337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P = 0.053) over the course of the study.
Conclusions: people with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health

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Published date: February 2010
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 73106
URI: https://eprints.soton.ac.uk/id/eprint/73106
ISSN: 0007-1250
PURE UUID: 32053a31-755f-46d8-af50-50c8078d5784
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

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Date deposited: 03 Mar 2010
Last modified: 06 Jun 2018 13:01

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Contributors

Author: Steve Brown
Author: Miranda Kim
Author: Clemence Mitchell
Author: Hazel Inskip ORCID iD

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