Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone

Carlotti, Emanuela, Wrench, David, Matthews, Janet, Iqbal, Sameena, Davies, Andrew, Norton, Andrew, Hart, Jason, Lai, Raymond, Montoto, Silvia, Gribben, John G., Lister, T. Andrew and Fitzgibbon, Jude (2009) Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone. Blood, 113 (15), 3553-3557. (doi:10.1182/blood-2008-08-174839).

Abstract

To investigate the cell of origin linking follicular (FL) and transformed (t-FL) lymphomas, we analyzed the somatic hypermutation (SHM) pattern of the variable region of the immunoglobulin heavy gene (IgH-VH) in 18 sequential FL/t-FL samples and a father (donor) and son (recipient), who developed FL and t-FL, after transplantation. Genealogic trees showed a pattern compatible with a common progenitor cell (CPC) origin in 13 cases. The identification of the t-FL clonotype in the previous FL sample and of the putative CPC sequence in both the FL/t-FL biopsies showed that the intraclonal diversity of FL and t-FL germinal centers (GCs) is more intricate than previously described, and all 3 clonotypes (CPC, FL, t-FL) may occur simultaneously within the same lymph node. On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease.

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Contributors

Author: Andrew Davies

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