The University of Southampton
University of Southampton Institutional Repository

Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone

Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone
Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone
To investigate the cell of origin linking follicular (FL) and transformed (t-FL) lymphomas, we analyzed the somatic hypermutation (SHM) pattern of the variable region of the immunoglobulin heavy gene (IgH-VH) in 18 sequential FL/t-FL samples and a father (donor) and son (recipient), who developed FL and t-FL, after transplantation. Genealogic trees showed a pattern compatible with a common progenitor cell (CPC) origin in 13 cases. The identification of the t-FL clonotype in the previous FL sample and of the putative CPC sequence in both the FL/t-FL biopsies showed that the intraclonal diversity of FL and t-FL germinal centers (GCs) is more intricate than previously described, and all 3 clonotypes (CPC, FL, t-FL) may occur simultaneously within the same lymph node. On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease.
0006-4971
3553-3557
Carlotti, Emanuela
4c033c02-5270-419a-bd5b-f6ce29395d91
Wrench, David
ef387e3b-ff45-404d-bf9e-ddc7f77373c1
Matthews, Janet
baa9d6ab-0e42-4ac6-8a95-48ce92acc38b
Iqbal, Sameena
5466a67e-c498-4a61-8f16-7aef3c81f1c9
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Norton, Andrew
9a78b66b-d789-4f21-911c-09de3f2af25e
Hart, Jason
11af4559-e670-4e59-9309-e8e82e8be3aa
Lai, Raymond
2efa8479-1ade-4538-9e3b-f23aa2278b17
Montoto, Silvia
890fe3f0-1910-49b4-97d4-993e2701052f
Gribben, John G.
8ae0a436-65bb-4397-b09f-5eac89bf08ef
Lister, T. Andrew
6b42a014-ee50-4017-bbb8-16aa71b74018
Fitzgibbon, Jude
6afae538-ec1c-41a0-af2a-21b98dfbb356
Carlotti, Emanuela
4c033c02-5270-419a-bd5b-f6ce29395d91
Wrench, David
ef387e3b-ff45-404d-bf9e-ddc7f77373c1
Matthews, Janet
baa9d6ab-0e42-4ac6-8a95-48ce92acc38b
Iqbal, Sameena
5466a67e-c498-4a61-8f16-7aef3c81f1c9
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Norton, Andrew
9a78b66b-d789-4f21-911c-09de3f2af25e
Hart, Jason
11af4559-e670-4e59-9309-e8e82e8be3aa
Lai, Raymond
2efa8479-1ade-4538-9e3b-f23aa2278b17
Montoto, Silvia
890fe3f0-1910-49b4-97d4-993e2701052f
Gribben, John G.
8ae0a436-65bb-4397-b09f-5eac89bf08ef
Lister, T. Andrew
6b42a014-ee50-4017-bbb8-16aa71b74018
Fitzgibbon, Jude
6afae538-ec1c-41a0-af2a-21b98dfbb356

Carlotti, Emanuela, Wrench, David, Matthews, Janet, Iqbal, Sameena, Davies, Andrew, Norton, Andrew, Hart, Jason, Lai, Raymond, Montoto, Silvia, Gribben, John G., Lister, T. Andrew and Fitzgibbon, Jude (2009) Transformation of follicular lymphoma to diffuse large B cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution form the follicular lymphoma clone. Blood, 113 (15), 3553-3557. (doi:10.1182/blood-2008-08-174839).

Record type: Article

Abstract

To investigate the cell of origin linking follicular (FL) and transformed (t-FL) lymphomas, we analyzed the somatic hypermutation (SHM) pattern of the variable region of the immunoglobulin heavy gene (IgH-VH) in 18 sequential FL/t-FL samples and a father (donor) and son (recipient), who developed FL and t-FL, after transplantation. Genealogic trees showed a pattern compatible with a common progenitor cell (CPC) origin in 13 cases. The identification of the t-FL clonotype in the previous FL sample and of the putative CPC sequence in both the FL/t-FL biopsies showed that the intraclonal diversity of FL and t-FL germinal centers (GCs) is more intricate than previously described, and all 3 clonotypes (CPC, FL, t-FL) may occur simultaneously within the same lymph node. On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease.

Full text not available from this repository.

More information

Published date: April 2009

Identifiers

Local EPrints ID: 73247
URI: https://eprints.soton.ac.uk/id/eprint/73247
ISSN: 0006-4971
PURE UUID: a503545c-33ae-4cf9-8b36-341bd01b528a

Catalogue record

Date deposited: 03 Mar 2010
Last modified: 19 Jul 2019 23:41

Export record

Altmetrics

Contributors

Author: Emanuela Carlotti
Author: David Wrench
Author: Janet Matthews
Author: Sameena Iqbal
Author: Andrew Davies
Author: Andrew Norton
Author: Jason Hart
Author: Raymond Lai
Author: Silvia Montoto
Author: John G. Gribben
Author: T. Andrew Lister
Author: Jude Fitzgibbon

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×