The University of Southampton
University of Southampton Institutional Repository

Maternal muscle mass may influence system A activity in human placenta

Lewis, R.M., Greenwood, S.L., Cleal, J.K., Crozier, S.R., Verrall, L., Inskip, H.M., Cameron, I.T., Cooper, C, Sibley, C.P., Hanson, M.A. and Godfrey, K.M. (2010) Maternal muscle mass may influence system A activity in human placenta Placenta, 31, (5)

Record type: Article


During pregnancy, nutrient partitioning between the mother and fetus must balance promoting fetal survival and maintaining nutritional status of the mother for her health and future fertility. The nutritional status of the pregnant woman, reflected in her body composition, may affect placental function with consequences for fetal development.

We investigated the relationship between maternal body composition and placental system A amino acid transporter activity in 103 term placentas from Southampton Women's Survey pregnancies.

Placental system A activity was measured as Na+-dependent uptake of 10 ?mol/L 14C-methylaminoisobutyric acid (a system A specific amino acid analogue) in placental villous fragments. Maternal body composition was measured at enrolment pre-pregnancy; in 45 infants neonatal body composition was measured using dual-energy x-ray absorptiometry.

Term placental system A activity was lower in women with smaller pre-pregnancy upper arm muscle area (r = 0.27, P = 0.007), but was not related to maternal fat mass. System A activity was lower in mothers who reported undertaking strenuous exercise (24.6 vs 29.7 pmol/mg/15 min in sedentary women, P = 0.03), but was not associated with other maternal lifestyle factors.

Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. This alteration may affect fetal development, altering fetal body composition, with long-term consequences

Full text not available from this repository.

More information

Published date: May 2010
Keywords: placenta, maternal body composition, amino acid transport, fetal


Local EPrints ID: 73301
ISSN: 0143-4004
PURE UUID: cea58367-c10e-476f-b2e7-54321b17d6f5
ORCID for R.M. Lewis: ORCID iD
ORCID for H.M. Inskip: ORCID iD
ORCID for I.T. Cameron: ORCID iD
ORCID for C Cooper: ORCID iD
ORCID for K.M. Godfrey: ORCID iD

Catalogue record

Date deposited: 04 Mar 2010
Last modified: 29 Aug 2017 02:03

Export record


Author: R.M. Lewis ORCID iD
Author: S.L. Greenwood
Author: J.K. Cleal
Author: S.R. Crozier
Author: L. Verrall
Author: H.M. Inskip ORCID iD
Author: I.T. Cameron ORCID iD
Author: C Cooper ORCID iD
Author: C.P. Sibley
Author: M.A. Hanson
Author: K.M. Godfrey ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.