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Maternal muscle mass may influence system A activity in human placenta

Lewis, R.M., Greenwood, S.L., Cleal, J.K., Crozier, S.R., Verrall, L., Inskip, H.M., Cameron, I.T., Cooper, C, Sibley, C.P., Hanson, M.A. and Godfrey, K.M. (2010) Maternal muscle mass may influence system A activity in human placenta Placenta, 31, (5)

Record type: Article

Abstract

During pregnancy, nutrient partitioning between the mother and fetus must balance promoting fetal survival and maintaining nutritional status of the mother for her health and future fertility. The nutritional status of the pregnant woman, reflected in her body composition, may affect placental function with consequences for fetal development.

We investigated the relationship between maternal body composition and placental system A amino acid transporter activity in 103 term placentas from Southampton Women's Survey pregnancies.

Placental system A activity was measured as Na+-dependent uptake of 10 ?mol/L 14C-methylaminoisobutyric acid (a system A specific amino acid analogue) in placental villous fragments. Maternal body composition was measured at enrolment pre-pregnancy; in 45 infants neonatal body composition was measured using dual-energy x-ray absorptiometry.

Term placental system A activity was lower in women with smaller pre-pregnancy upper arm muscle area (r = 0.27, P = 0.007), but was not related to maternal fat mass. System A activity was lower in mothers who reported undertaking strenuous exercise (24.6 vs 29.7 pmol/mg/15 min in sedentary women, P = 0.03), but was not associated with other maternal lifestyle factors.

Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. This alteration may affect fetal development, altering fetal body composition, with long-term consequences

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More information

Published date: May 2010
Keywords: placenta, maternal body composition, amino acid transport, fetal

Identifiers

Local EPrints ID: 73301
URI: http://eprints.soton.ac.uk/id/eprint/73301
ISSN: 0143-4004
PURE UUID: cea58367-c10e-476f-b2e7-54321b17d6f5
ORCID for R.M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for I.T. Cameron: ORCID iD orcid.org/0000-0002-4875-267X
ORCID for C Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 04 Mar 2010
Last modified: 29 Aug 2017 02:03

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Contributors

Author: R.M. Lewis ORCID iD
Author: S.L. Greenwood
Author: J.K. Cleal
Author: S.R. Crozier
Author: L. Verrall
Author: H.M. Inskip ORCID iD
Author: I.T. Cameron ORCID iD
Author: C Cooper ORCID iD
Author: C.P. Sibley
Author: M.A. Hanson
Author: K.M. Godfrey ORCID iD

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