Clinical and molecular prognostic factors in follicular lymphoma
Clinical and molecular prognostic factors in follicular lymphoma
The observed variability in the clinical course of follicular lymphoma (FL), along with the diverse range of therapeutic options available, necessitates accurate prognostic stratification of the individual patient. A number of clinical, laboratory, and pathologic parameters have been associated with both good and poor risk disease; in some instances these have been incorporated into readily calculable prognostic indices. With new insights into disease biology and the resulting identification of biomarkers that have arisen from the analysis of both the genome and the transcriptome, more accurate individualization of prognosis will be realized. At present the clinical application of such biomarkers, however, remains largely in its infancy. This review examines the clinical and molecular prognostic features that have been identified as of value in FL.
359-367
Davies, Andrew J.
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
October 2006
Davies, Andrew J.
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Davies, Andrew J.
(2006)
Clinical and molecular prognostic factors in follicular lymphoma.
Current Oncology Reports, 8 (5), .
(doi:10.1007/s11912-006-0059-8).
Abstract
The observed variability in the clinical course of follicular lymphoma (FL), along with the diverse range of therapeutic options available, necessitates accurate prognostic stratification of the individual patient. A number of clinical, laboratory, and pathologic parameters have been associated with both good and poor risk disease; in some instances these have been incorporated into readily calculable prognostic indices. With new insights into disease biology and the resulting identification of biomarkers that have arisen from the analysis of both the genome and the transcriptome, more accurate individualization of prognosis will be realized. At present the clinical application of such biomarkers, however, remains largely in its infancy. This review examines the clinical and molecular prognostic features that have been identified as of value in FL.
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Published date: October 2006
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Local EPrints ID: 73329
URI: http://eprints.soton.ac.uk/id/eprint/73329
ISSN: 1523-3790
PURE UUID: a7e37316-276e-4675-a384-796efe9394ab
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Date deposited: 11 Mar 2010
Last modified: 14 Mar 2024 02:54
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