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Hematopoietic stem cell transplantation in non-Hodgkin lymphoma

Hematopoietic stem cell transplantation in non-Hodgkin lymphoma
Hematopoietic stem cell transplantation in non-Hodgkin lymphoma

Purpose of review: Although high-dose therapy with stem cell transplantation (SCT) has become standard of care in patients with chemotherapy-sensitive relapse of 'aggressive' non-Hodgkin lymphoma (NHL), its role both at the time of disease presentation and in other histologic subtypes of NHL remains controversial. Emerging data on allogeneic transplantation have also led to renewed interest in NHL. We review recent literature in this field.

Recent findings: In 'aggressive' lymphoma, a randomized study has demonstrated the superiority of an intensive regimen over conventional CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone in patients with high-intermediate International Prognostic Index scores. Similarly, at recurrence of follicular lymphoma, high-dose therapy and SCT provide an advantage in progression-free and overall survival over conventional chemotherapy but demonstrated no benefit from ex-vivo purging. Data continue to mount supporting a role for allogeneic transplantation with reduced-intensity conditioning regimens and furthermore a graft-versus-lymphoma effect in some clinical settings in NHL.

Summary: The role of both autologous and allogeneic SCT in NHL continues to evolve. Randomized trials are helping define the place for such strategies; however, because of the relative rarity of some histologic subtypes, such studies may not be feasible. The maturation of well-conducted phase II studies and registry data are pivotal to guiding us under these circumstances.
1087-2418
35-39
Davies, Andrew J.
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Gribben, John G.
8ae0a436-65bb-4397-b09f-5eac89bf08ef
Davies, Andrew J.
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Gribben, John G.
8ae0a436-65bb-4397-b09f-5eac89bf08ef

Davies, Andrew J. and Gribben, John G. (2005) Hematopoietic stem cell transplantation in non-Hodgkin lymphoma. Current Opinion In Organ Transplantation, 10 (1), 35-39. (doi:10.1097/01.mot.0000152690.24829.ca).

Record type: Article

Abstract


Purpose of review: Although high-dose therapy with stem cell transplantation (SCT) has become standard of care in patients with chemotherapy-sensitive relapse of 'aggressive' non-Hodgkin lymphoma (NHL), its role both at the time of disease presentation and in other histologic subtypes of NHL remains controversial. Emerging data on allogeneic transplantation have also led to renewed interest in NHL. We review recent literature in this field.

Recent findings: In 'aggressive' lymphoma, a randomized study has demonstrated the superiority of an intensive regimen over conventional CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone in patients with high-intermediate International Prognostic Index scores. Similarly, at recurrence of follicular lymphoma, high-dose therapy and SCT provide an advantage in progression-free and overall survival over conventional chemotherapy but demonstrated no benefit from ex-vivo purging. Data continue to mount supporting a role for allogeneic transplantation with reduced-intensity conditioning regimens and furthermore a graft-versus-lymphoma effect in some clinical settings in NHL.

Summary: The role of both autologous and allogeneic SCT in NHL continues to evolve. Randomized trials are helping define the place for such strategies; however, because of the relative rarity of some histologic subtypes, such studies may not be feasible. The maturation of well-conducted phase II studies and registry data are pivotal to guiding us under these circumstances.

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Published date: March 2005

Identifiers

Local EPrints ID: 73336
URI: http://eprints.soton.ac.uk/id/eprint/73336
ISSN: 1087-2418
PURE UUID: 6bd22f52-fd35-4b80-9ded-9a5e8dce4561
ORCID for Andrew J. Davies: ORCID iD orcid.org/0000-0002-7517-6938

Catalogue record

Date deposited: 11 Mar 2010
Last modified: 30 Apr 2020 00:31

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