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Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion

Silberstein, L., Davies, A., Kelsey, S., Foran, J., Murrell, C., D'Cruz, D., Vinnicombe, S., Norton, A. and Cavenagh, J. (2001) Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion Bone Marrow Transplantation, 27, (2), pp. 231-233. (doi:10.1038/sj.bmt.1702775).

Record type: Article

Abstract

The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodgkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.

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Published date: January 2001

Identifiers

Local EPrints ID: 73365
URI: http://eprints.soton.ac.uk/id/eprint/73365
ISSN: 0268-3369
PURE UUID: 0de84327-e308-400d-9234-6e97cf241ea9

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Date deposited: 09 Mar 2010
Last modified: 18 Jul 2017 23:50

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Contributors

Author: L. Silberstein
Author: A. Davies
Author: S. Kelsey
Author: J. Foran
Author: C. Murrell
Author: D. D'Cruz
Author: S. Vinnicombe
Author: A. Norton
Author: J. Cavenagh

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