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Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion

Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion
Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion
The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodgkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.
0268-3369
231-233
Silberstein, L.
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Davies, A.
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Kelsey, S.
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Foran, J.
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Murrell, C.
eadf6888-01f6-4ed4-be34-149a6b2bcfd4
D'Cruz, D.
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Vinnicombe, S.
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Norton, A.
8b9588e9-1da1-4119-8ae7-576d2fcfbedc
Cavenagh, J.
c50d6e67-15c2-4b22-bbde-92903b0e7ccf
Silberstein, L.
9f396207-51f8-4957-8770-a69c4f3f240f
Davies, A.
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Kelsey, S.
70bbcf95-9bf4-4e48-a693-9e2e5a4b1eb7
Foran, J.
58f685bc-b66e-42f2-b1f3-640407002b4f
Murrell, C.
eadf6888-01f6-4ed4-be34-149a6b2bcfd4
D'Cruz, D.
1a26cd58-83d2-4f9f-80bf-401d28989279
Vinnicombe, S.
76f44048-c7f0-4a79-968c-41d7ece30e6b
Norton, A.
8b9588e9-1da1-4119-8ae7-576d2fcfbedc
Cavenagh, J.
c50d6e67-15c2-4b22-bbde-92903b0e7ccf

Silberstein, L., Davies, A., Kelsey, S., Foran, J., Murrell, C., D'Cruz, D., Vinnicombe, S., Norton, A. and Cavenagh, J. (2001) Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion. Bone Marrow Transplantation, 27 (2), 231-233. (doi:10.1038/sj.bmt.1702775).

Record type: Article

Abstract

The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodgkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.

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Published date: January 2001

Identifiers

Local EPrints ID: 73365
URI: http://eprints.soton.ac.uk/id/eprint/73365
ISSN: 0268-3369
PURE UUID: 0de84327-e308-400d-9234-6e97cf241ea9
ORCID for A. Davies: ORCID iD orcid.org/0000-0002-7517-6938

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Date deposited: 09 Mar 2010
Last modified: 14 Mar 2024 02:54

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Contributors

Author: L. Silberstein
Author: A. Davies ORCID iD
Author: S. Kelsey
Author: J. Foran
Author: C. Murrell
Author: D. D'Cruz
Author: S. Vinnicombe
Author: A. Norton
Author: J. Cavenagh

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