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Rectal cancer staging post neoadjuvant therapy - how should the changes be assessed?

Rectal cancer staging post neoadjuvant therapy - how should the changes be assessed?
Rectal cancer staging post neoadjuvant therapy - how should the changes be assessed?
Aims:To compare the utility and reproducibility of tumour regression grade scoring systems during histopathological assessment of rectal cancers resected after neoadjuvant (i.e. pre-operative) chemoradiotherapy. Methods and results:?
The histopathological features of tumour regression were assessed independently in 54 rectal cancer resection specimens using three scoring systems: the Tumour Regression Grade (TRG), modified Rectal Cancer Regression Grade (m-RCRG) and RCPath Cancer Dataset (RCPath) methods. Good interobserver agreement was achieved for all three systems (? scores: TRG system 0.719, m-RCRG system 0.734, RCPath system 0.742). Both observers diagnosed complete tumour regression and little/no regression in 11 cases (20% of all cases) and four cases (11% of all cases), respectively. A mean of 5.6 tumour blocks/case were taken and the mean lymph node yield was 8.4/case. Conclusions:?
All three scoring systems were usable in a diagnostic setting. The clinical significance of differing degrees of tumour regression is not yet universally agreed and, with this in mind, the m-RCRG system provided the optimum balance between applicability and the accurate recording of low, moderate and high degrees of tumour regression, thus facilitating future clinicopathological studies of moderate and high degrees of tumour regression and clinical outcome.
colorectal cancer, inter-observer agreement, neoadjuvant therapy, regression, staging
1365-2559
713-721
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Jaynes, Eleanor
dae2d9a2-5cda-46a4-aa7e-4d04e495fe65
Bateman, Andrew R.
a851558d-8b9b-4020-b148-a239c2b26815
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Jaynes, Eleanor
dae2d9a2-5cda-46a4-aa7e-4d04e495fe65
Bateman, Andrew R.
a851558d-8b9b-4020-b148-a239c2b26815

Bateman, Adrian C., Jaynes, Eleanor and Bateman, Andrew R. (2009) Rectal cancer staging post neoadjuvant therapy - how should the changes be assessed? Histopathology, 54 (6), 713-721.

Record type: Article

Abstract

Aims:To compare the utility and reproducibility of tumour regression grade scoring systems during histopathological assessment of rectal cancers resected after neoadjuvant (i.e. pre-operative) chemoradiotherapy. Methods and results:?
The histopathological features of tumour regression were assessed independently in 54 rectal cancer resection specimens using three scoring systems: the Tumour Regression Grade (TRG), modified Rectal Cancer Regression Grade (m-RCRG) and RCPath Cancer Dataset (RCPath) methods. Good interobserver agreement was achieved for all three systems (? scores: TRG system 0.719, m-RCRG system 0.734, RCPath system 0.742). Both observers diagnosed complete tumour regression and little/no regression in 11 cases (20% of all cases) and four cases (11% of all cases), respectively. A mean of 5.6 tumour blocks/case were taken and the mean lymph node yield was 8.4/case. Conclusions:?
All three scoring systems were usable in a diagnostic setting. The clinical significance of differing degrees of tumour regression is not yet universally agreed and, with this in mind, the m-RCRG system provided the optimum balance between applicability and the accurate recording of low, moderate and high degrees of tumour regression, thus facilitating future clinicopathological studies of moderate and high degrees of tumour regression and clinical outcome.

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More information

Published date: May 2009
Keywords: colorectal cancer, inter-observer agreement, neoadjuvant therapy, regression, staging

Identifiers

Local EPrints ID: 73395
URI: https://eprints.soton.ac.uk/id/eprint/73395
ISSN: 1365-2559
PURE UUID: 6057ce70-55a3-4d9e-9a6b-1c9ddd801706

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Date deposited: 05 Mar 2010
Last modified: 08 Nov 2017 17:34

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