Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease
Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 10-157) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 10-9) and 5' to the PICALM gene (rs3851179, P = 1.9 10-8). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 10-10, odds ratio = 0.86; rs3851179, P = 1.3 10-9, odds ratio = 0.86).
1088-1093
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Morgan, Angharad R.
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Lovestone, Simon
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Lupton, Michelle K.
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Holmes, Clive
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Guerreiro, Rita
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Muhleisen, Thomas W.
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Moebus, Susanne
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Jockel, Karl Heinz
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Klopp, Norman
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Wichmann, H.Erich
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Carrasquillo, Minerva M
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Holmans, Peter A.
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O'Donovan, Michael
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Owen, Michael J.
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Williams, Julie
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2009
Harold, Denise
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Abraham, Richard
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Hollingworth, Paul
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Sims, Rebecca
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Gerrish, Amy
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Hamshere, Marian L.
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Pahwa, Jaspreet Sing
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Moskvina, Valentina
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Dowzell, Kimberley
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Williams, Amy
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Thomas, Charlene
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Stretton, Alexandra
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Morgan, Angharad R.
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Lovestone, Simon
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