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Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire cohort study

Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire cohort study
Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire cohort study
Background: reduced grip strength is associated with adverse health consequences, and there is interest in identifying modifiable influences. Cardiovascular drugs are commonly used by older people, but their effect on muscle strength is unclear.
Methods: we investigated associations between cardiovascular drug use and grip strength among 1,572 men and 1,415 women, aged 59–73, who participated in the Hertfordshire Cohort Study.
Results: forty-five percent of participants were taking a cardiovascular drug. Furosemide was associated with average decreases in grip strength of 3.15 kg (95% confidence interval [CI] 0.90, 5.39, P < 0.01) among men and 2.35 kg (95% CI 0.93, 3.77, P < 0.01) among women after adjustment for age and height. Corresponding differences for nitrates were 1.84 kg (95% CI 0.29, 3.39, P = 0.02) among men and 3.66 kg (95% CI 1.99, 5.33, P < 0.01) among women. Calcium channel blockers and fibrates were associated with reduced grip among women. Statins were not associated with grip. The associations between grip strength and nitrate use in men and nitrate and fibrate use in women were robust to additional adjustment for co-morbidity.
Conclusions: use of some cardiovascular drugs is associated with reduced grip strength in older people. These findings have potential implications for the functional ability of older people treated with these drugs
grip strength, sarcopenia, cardiovascular drugs, ageing, elderly
0002-0729
185-191
Ashfield, T.A.
611947e4-b339-4943-b4cc-f0ec98d5a0d9
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Ashfield, T.A.
611947e4-b339-4943-b4cc-f0ec98d5a0d9
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb

Ashfield, T.A., Syddall, H.E., Martin, H.J., Dennison, E.M., Cooper, C. and Aihie Sayer, A. (2009) Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire cohort study. Age and Ageing, 39 (2), 185-191. (doi:10.1093/ageing/afp203).

Record type: Article

Abstract

Background: reduced grip strength is associated with adverse health consequences, and there is interest in identifying modifiable influences. Cardiovascular drugs are commonly used by older people, but their effect on muscle strength is unclear.
Methods: we investigated associations between cardiovascular drug use and grip strength among 1,572 men and 1,415 women, aged 59–73, who participated in the Hertfordshire Cohort Study.
Results: forty-five percent of participants were taking a cardiovascular drug. Furosemide was associated with average decreases in grip strength of 3.15 kg (95% confidence interval [CI] 0.90, 5.39, P < 0.01) among men and 2.35 kg (95% CI 0.93, 3.77, P < 0.01) among women after adjustment for age and height. Corresponding differences for nitrates were 1.84 kg (95% CI 0.29, 3.39, P = 0.02) among men and 3.66 kg (95% CI 1.99, 5.33, P < 0.01) among women. Calcium channel blockers and fibrates were associated with reduced grip among women. Statins were not associated with grip. The associations between grip strength and nitrate use in men and nitrate and fibrate use in women were robust to additional adjustment for co-morbidity.
Conclusions: use of some cardiovascular drugs is associated with reduced grip strength in older people. These findings have potential implications for the functional ability of older people treated with these drugs

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More information

Published date: 17 December 2009
Keywords: grip strength, sarcopenia, cardiovascular drugs, ageing, elderly

Identifiers

Local EPrints ID: 73487
URI: https://eprints.soton.ac.uk/id/eprint/73487
ISSN: 0002-0729
PURE UUID: 4bc8be60-a984-4580-abf0-32cc260dff96
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 08 Mar 2010
Last modified: 10 Jan 2019 01:37

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Contributors

Author: T.A. Ashfield
Author: H.E. Syddall ORCID iD
Author: H.J. Martin
Author: E.M. Dennison ORCID iD
Author: C. Cooper ORCID iD
Author: A. Aihie Sayer

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