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T cells orchestrate intestinal mucosal shape and integrity

T cells orchestrate intestinal mucosal shape and integrity
T cells orchestrate intestinal mucosal shape and integrity
T helper 1-type immune reactions in the gut cause important human diseases, such as Crohn's disease and coeliac disease. Here, Tom MacDonald, Mona Elliott and Sylvia Pender suggest that the tissue injury in these diseases is mediated not by the immune cells, but by cytokine-induced changes in keratinocyte growth factor and matrix metalloproteinase production by resident gut myofibroblasts.
0167-5699
505-510
MacDonald, Thomas T.
a6bde8a9-acc4-4128-851f-dd5dbfe28816
Bajaj-Elliott, Mona
fc2e7499-178b-4611-84ed-68febf5d8930
Pender, Sylvia L. F.
62528b03-ec42-41bb-80fe-48454c2c5242
MacDonald, Thomas T.
a6bde8a9-acc4-4128-851f-dd5dbfe28816
Bajaj-Elliott, Mona
fc2e7499-178b-4611-84ed-68febf5d8930
Pender, Sylvia L. F.
62528b03-ec42-41bb-80fe-48454c2c5242

MacDonald, Thomas T., Bajaj-Elliott, Mona and Pender, Sylvia L. F. (1999) T cells orchestrate intestinal mucosal shape and integrity. Immunology Today, 20 (11), 505-510. (doi:10.1016/S0167-5699(99)01536-4).

Record type: Article

Abstract

T helper 1-type immune reactions in the gut cause important human diseases, such as Crohn's disease and coeliac disease. Here, Tom MacDonald, Mona Elliott and Sylvia Pender suggest that the tissue injury in these diseases is mediated not by the immune cells, but by cytokine-induced changes in keratinocyte growth factor and matrix metalloproteinase production by resident gut myofibroblasts.

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Published date: November 1999
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Identifiers

Local EPrints ID: 73606
URI: http://eprints.soton.ac.uk/id/eprint/73606
DOI: doi:10.1016/S0167-5699(99)01536-4
ISSN: 0167-5699
PURE UUID: a5c7390b-f066-4c83-8171-f2d286e3e208
ORCID for Sylvia L. F. Pender: ORCID iD orcid.org/0000-0001-6332-0333

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Date deposited: 10 Mar 2010
Last modified: 14 Mar 2024 02:45

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Contributors

Author: Thomas T. MacDonald
Author: Mona Bajaj-Elliott
Author: Sylvia L. F. Pender ORCID iD

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