Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory and delay-related impairments in Attention Deficit/Hyperactivity Disorder
Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory and delay-related impairments in Attention Deficit/Hyperactivity Disorder
Objective: the dual pathway model explains neuro-psychological heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) in terms of dissociable cognitive and motivational deficits each affecting some but not other patients. We explore whether deficits in temporal processing might constitute a third dissociable neuropsychological component of ADHD.
Method: nine tasks designed to tap three domains (inhibitory control, delay aversion and temporal processing) were administered to ADHD probands (n=71; ages 6 to 17 years), their siblings (n=71; 65 unaffected by ADHD) and a group of non-ADHD controls (n=50). IQ and working memory were measured.
Results: temporal processing, inhibitory control and delay-related deficits represented independent neuropsychological components. ADHD children differed from controls on all factors. For ADHD patients, the co-occurrence of inhibitory, temporal processing and delay-related deficits was no greater than expected by chance with substantial groups of patients showing only one problem. Domain-specific patterns of familial co-segregation provided evidence for the validity of neuropsychological subgroupings.
Conclusion: the current results illustrate the neuropsychological heterogeneity in ADHD and initial support for a triple pathway model. The findings need to be replicated in larger samples
adhd, delay aversion, heterogeneity, inhibitory control, timing
345-355
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Bitsakou, Paraskevi
68ff8113-a215-4cee-9897-a047acdc65e8
Thompson, Margaret
bfe8522c-b252-4771-8036-744e93357c67
8 March 2010
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Bitsakou, Paraskevi
68ff8113-a215-4cee-9897-a047acdc65e8
Thompson, Margaret
bfe8522c-b252-4771-8036-744e93357c67
Sonuga-Barke, Edmund, Bitsakou, Paraskevi and Thompson, Margaret
(2010)
Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory and delay-related impairments in Attention Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child and Adolescent Psychiatry, 49 (4), .
(doi:10.1016/j.jaac.2009.12.018).
Abstract
Objective: the dual pathway model explains neuro-psychological heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) in terms of dissociable cognitive and motivational deficits each affecting some but not other patients. We explore whether deficits in temporal processing might constitute a third dissociable neuropsychological component of ADHD.
Method: nine tasks designed to tap three domains (inhibitory control, delay aversion and temporal processing) were administered to ADHD probands (n=71; ages 6 to 17 years), their siblings (n=71; 65 unaffected by ADHD) and a group of non-ADHD controls (n=50). IQ and working memory were measured.
Results: temporal processing, inhibitory control and delay-related deficits represented independent neuropsychological components. ADHD children differed from controls on all factors. For ADHD patients, the co-occurrence of inhibitory, temporal processing and delay-related deficits was no greater than expected by chance with substantial groups of patients showing only one problem. Domain-specific patterns of familial co-segregation provided evidence for the validity of neuropsychological subgroupings.
Conclusion: the current results illustrate the neuropsychological heterogeneity in ADHD and initial support for a triple pathway model. The findings need to be replicated in larger samples
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Published date: 8 March 2010
Keywords:
adhd, delay aversion, heterogeneity, inhibitory control, timing
Organisations:
Clinical Neurosciences
Identifiers
Local EPrints ID: 73697
URI: http://eprints.soton.ac.uk/id/eprint/73697
ISSN: 1527-5418
PURE UUID: 44cd5823-4fa1-4a32-a34a-fb93a84702a7
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Date deposited: 16 Mar 2010
Last modified: 13 Mar 2024 22:14
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Author:
Edmund Sonuga-Barke
Author:
Paraskevi Bitsakou
Author:
Margaret Thompson
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