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Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo

Boomsma, Carolien M., Kavelaars, Annemieke, Eijkemans, Marinus J.C., Fauser, Bart C.J.M., Heijnen, Cobi J. and Macklon, Nick S. (2009) Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo Fertility and Sterility, 94, (5), pp. 1764-1768. (doi:10.1016/j.fertnstert.2009.10.044).

Record type: Article


Objective: to elucidate the impact of ovarian stimulation on the intrauterine milieu represented by the cytokine, chemokine, and growth factor profile in endometrial secretions aspirated before embryo transfer.

Design: prospective cohort study.

Setting: fertility center in tertiary referral university hospital.

Patient(s): forty-two patients undergoing ovarian stimulation with GnRH analogues were recruited. They participated in both a natural and an ovarian-stimulated cycle for within patient comparisons.

Interventions(s): endometrial secretion aspiration was performed immediately before embryo transfer.

Main outcome measure(s): the concentrations of 17 mediators known to be involved in human embryo implantation were assessed by multiplex immunoassay.

Result(s): after correction for multiple testing, significantly higher concentrations of interleukin (IL)-1beta, IL-5, IL-10, IL-12, IL-17, tumor necrosis factor (TNF)-alpha, heparin-binding epidermal growth factor (HbEGF), eotaxin, and dickkopf homologue-1 were present in endometrial secretions obtained in stimulated compared with natural cycles.

Conclusion(s): endometrial secretion analysis provides a novel means of investigating the effect of ovarian stimulation on the intrauterine milieu. The in vivo milieu encountered by the embryo after transfer is significantly altered by ovarian stimulation.

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More information

Published date: 10 December 2009
Keywords: ovarian stimulation, endometrium, cytokine, in vitro fertilization
Organisations: Dev Origins of Health & Disease, Human Development & Health


Local EPrints ID: 76214
ISSN: 0015-0282
PURE UUID: 6c40ed6b-bafd-438e-83a2-aca9518d4752

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Date deposited: 11 Mar 2010
Last modified: 18 Jul 2017 23:41

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Author: Carolien M. Boomsma
Author: Annemieke Kavelaars
Author: Marinus J.C. Eijkemans
Author: Bart C.J.M. Fauser
Author: Cobi J. Heijnen
Author: Nick S. Macklon

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