The University of Southampton
University of Southampton Institutional Repository

A review of techniques for adhesion prevention after gynaecological surgery

Metwally, Mostafa, Cheong, Ying and Li, Tin Chiu (2008) A review of techniques for adhesion prevention after gynaecological surgery Current Opinion in Obstetrics and Gynecology, 20, (4), pp. 345-352. (doi:10.1097/GCO.0b013e3283073a6c). (PMID:18660685).

Record type: Article


Purpose of review: to explore recent developments in the techniques used for the prevention of adhesion formation after gynaecological surgery as well as the current evidence for existing agents and techniques.

Recent findings: recent developments are promising new biomaterials such as polyvinyl alcohol gel and hyaluronic acid cross-linked with various agents such as nanoparticles. Other substances that have recently received attention include novel anti-inflammatory agents, Oxiplex (FzioMed, Inc., San Luis Obispo, California, USA), sildenafil, statins and also, there has been some renewed interest in dextran. Furthermore, the combination of barrier and pharmacological agents has led to the introduction of interesting new hybrid systems. Finally, despite the development of many novel antiadhesion agents, good surgical technique remains the mainstay of adhesion prevention.

Summary: there is preliminary evidence to support the use of hyaluronic acid, although the best preparation is yet to be determined. The use of icodextrin, Interceed (Ethicon Inc, Somerville, New Jersey, USA) and Oxiplex seem to be justified by the currently available data. The results of interesting new technologies such as the use of hybrid systems and new forms of biomaterials are awaited.

Full text not available from this repository.

More information

Published date: August 2008


Local EPrints ID: 76225
ISSN: 1040-872X
PURE UUID: 3f4c5d39-bd54-45af-bb31-764c3cd845a8
ORCID for Ying Cheong: ORCID iD

Catalogue record

Date deposited: 15 Mar 2010
Last modified: 18 Jul 2017 23:41

Export record



Author: Mostafa Metwally
Author: Ying Cheong ORCID iD
Author: Tin Chiu Li

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.