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Integrated optical Mach-Zehnder biosensor

Integrated optical Mach-Zehnder biosensor
Integrated optical Mach-Zehnder biosensor
We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer. The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm2.
0733-8724
583-592
Luff, B.J.
04d280ab-ae84-4715-9dad-6a1120050ccd
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Piehler, J.
c7ccd012-3ad1-4b8a-aa0c-6244ab00630f
Hollenbach, U.
0970c5f2-916e-4c69-948b-1ccce2829447
Ingenhoff, J.
222a9715-7807-4f92-8001-81789ee165de
Fabricius, N.
ec9649c9-ad3e-41b6-b1ba-f5ab22a7b32a
Luff, B.J.
04d280ab-ae84-4715-9dad-6a1120050ccd
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Piehler, J.
c7ccd012-3ad1-4b8a-aa0c-6244ab00630f
Hollenbach, U.
0970c5f2-916e-4c69-948b-1ccce2829447
Ingenhoff, J.
222a9715-7807-4f92-8001-81789ee165de
Fabricius, N.
ec9649c9-ad3e-41b6-b1ba-f5ab22a7b32a

Luff, B.J., Wilkinson, J.S., Piehler, J., Hollenbach, U., Ingenhoff, J. and Fabricius, N. (1998) Integrated optical Mach-Zehnder biosensor. IEEE Journal of Lightwave Technology, 16 (4), 583-592. (doi:10.1109/50.664067).

Record type: Article

Abstract

We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer. The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm2.

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More information

Published date: 1998
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 77975
URI: https://eprints.soton.ac.uk/id/eprint/77975
ISSN: 0733-8724
PURE UUID: ffaa0e1c-3a16-49ec-b136-9515bcbb9872
ORCID for J.S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 11 Mar 2010
Last modified: 18 Jul 2019 01:26

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