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Non-invasive, optical measurement of absolute blood volume in haemodialysis patients

Johnson, David W., McMahon, Miriam, Campbell, Scott, Wilkinson, James, Kime, Neil, Shannon, Gerald and Fleming, Simon J. (1996) Non-invasive, optical measurement of absolute blood volume in haemodialysis patients Kidney International, 49, (1), pp. 255-260. (doi:10.1038/ki.1996.36). (PMID:8770977).

Record type: Article


During haemodialysis, fluid is removed from, or infused into patients after careful clinical assessment of their hydration states. Unfortunately, these assessments are often imprecise, resulting in either fluid overload or intravascular volume depletion. Since hypovolaemia plays an important role in symptomatic hypotension, which complicates up to 25% of dialysis treatments, there has been increased interest in blood volume (BV) monitoring in recent years. Previous authors have suggested monitoring change in BV during dialysis by examining alterations in optical density, optical reflection, mass density, viscosity, protein concentration or electrical conductivity. However, none of these described methods has measured absolute BV, which is at least as important a determinant of dialysis-related hypotension as the relative change in BV. The best method currently available is measurement of red cell and plasma volumes by dilution of radioactively labelled blood elements. The time-consuming nature of this method and the exposure of the patient to radiation makes it unsuitable for routine clinical use, especially if a number of studies are required.

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Published date: January 1996


Local EPrints ID: 78127
ISSN: 0085-2538
PURE UUID: 4edbc1ad-0abf-4f02-916c-72cc8181dbdd
ORCID for James Wilkinson: ORCID iD

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Date deposited: 11 Mar 2010
Last modified: 18 Jul 2017 23:26

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Author: David W. Johnson
Author: Miriam McMahon
Author: Scott Campbell
Author: James Wilkinson ORCID iD
Author: Neil Kime
Author: Gerald Shannon
Author: Simon J. Fleming

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