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The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia

The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia
The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia
In 15 patients with primary dystonia (six cervical and nine generalized dystonias) who were treated with bilateral chronic pallidal stimulation, we investigated the sensorimotor modulation of the oscillatory local field potentials (LFPs) recorded from the pallidal electrodes. We correlated these with the surface electromyograms in the affected muscles. The effects of involuntary, passive and voluntary movement and muscle-tendon vibration on frequency ranges of 0–3 Hz, theta (3–8 Hz), alpha (8–12 Hz), low (12–20 Hz) and high beta (20–30 Hz), and low (30–60 Hz) and high gamma (60–90 Hz) power were recorded and compared between cervical and generalized dystonia groups. Significant decreases in LFP synchronization at 8–20 Hz occurred during the sensory modulation produced by voluntary or passive movement or vibration. Voluntary movement also caused increased gamma band activity (30–90 Hz). Dystonic involuntary muscle spasms were specifically associated with increased theta, alpha and low beta (3–18 Hz). Furthermore, the increase in the frequency range of 3–20 Hz correlated with the strength of the muscle spasms and preceded them by ~320 ms. Differences in modulation of pallidal oscillation between cervical and generalized dystonias were also revealed. This study yields new insights into the pathophysiological mechanisms of primary dystonias and their treatment using pallidal deep brain stimulation.
dystonia, deep brain stimulation, electromyograms, globus pallidus, oscillations
0006-8950
1562-1573
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Nandi, Dipankar
bb04275c-5921-4175-9c17-0b819a1213b0
Bain, Peter G.
a9691e26-7129-4eae-80b8-29e76b0ba31b
Gregory, Ralph
2a0c3f26-d503-497f-a130-96302a61580b
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Nandi, Dipankar
bb04275c-5921-4175-9c17-0b819a1213b0
Bain, Peter G.
a9691e26-7129-4eae-80b8-29e76b0ba31b
Gregory, Ralph
2a0c3f26-d503-497f-a130-96302a61580b
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0

Liu, Xuguang, Wang, Shouyan, Yianni, John, Nandi, Dipankar, Bain, Peter G., Gregory, Ralph, Stein, John F. and Aziz, Tipu Z. (2008) The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia. Brain, 131 (6), 1562-1573. (doi:10.1093/brain/awn083).

Record type: Article

Abstract

In 15 patients with primary dystonia (six cervical and nine generalized dystonias) who were treated with bilateral chronic pallidal stimulation, we investigated the sensorimotor modulation of the oscillatory local field potentials (LFPs) recorded from the pallidal electrodes. We correlated these with the surface electromyograms in the affected muscles. The effects of involuntary, passive and voluntary movement and muscle-tendon vibration on frequency ranges of 0–3 Hz, theta (3–8 Hz), alpha (8–12 Hz), low (12–20 Hz) and high beta (20–30 Hz), and low (30–60 Hz) and high gamma (60–90 Hz) power were recorded and compared between cervical and generalized dystonia groups. Significant decreases in LFP synchronization at 8–20 Hz occurred during the sensory modulation produced by voluntary or passive movement or vibration. Voluntary movement also caused increased gamma band activity (30–90 Hz). Dystonic involuntary muscle spasms were specifically associated with increased theta, alpha and low beta (3–18 Hz). Furthermore, the increase in the frequency range of 3–20 Hz correlated with the strength of the muscle spasms and preceded them by ~320 ms. Differences in modulation of pallidal oscillation between cervical and generalized dystonias were also revealed. This study yields new insights into the pathophysiological mechanisms of primary dystonias and their treatment using pallidal deep brain stimulation.

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More information

Published date: 28 May 2008
Keywords: dystonia, deep brain stimulation, electromyograms, globus pallidus, oscillations
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 79201
URI: https://eprints.soton.ac.uk/id/eprint/79201
ISSN: 0006-8950
PURE UUID: cfa5e2d2-2d6b-4fe3-ad25-4051e844bd0b

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Date deposited: 15 Mar 2010
Last modified: 17 Jul 2019 00:12

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