The University of Southampton
University of Southampton Institutional Repository

Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation

Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz ([Brown et al., 2001], [Kuhn et al., 2004] and [Priori et al., 2004]) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (Kuhn et al., 2006). It has also been shown that improvements in motor symptoms after dopamine correlate with single unit activity in the beta range (Weinberger et al., 2006). We recorded local field potentials (LFPs) from the subthalamic nucleus of patients with Parkinson's disease (PD) after surgery to implant deep brain stimulating electrodes while they were on and off dopaminergic medication. As well as replicating Kuhn et al., using the same patients we were able to extend Weinberger et al. to show that LFP beta oscillatory activity correlated with the degree of improvement in bradykinesia/rigidity, but not tremor, after dopamine medication. We also found that the power of beta oscillatory activity uniquely predicted improvements in bradykinesia/rigidity, but again not tremor, after stimulation of the STN in a regression analysis. However improvements after STN stimulation related inversely to beta power, possibly reflecting the accuracy of the electrode placement and/or the limits of STN stimulation in patients with the greatest levels of beta oscillatory activity
0014-4886
108-113
Ray, N.J.
136d01d6-b4c3-4db9-a6c5-0d03d4ffa34c
Jenkinson, N.
6bf2c89f-decb-48ef-b1a1-a05779a64779
Wang, S.
a2223997-9f42-425b-b0c6-1bcb64d9b8fc
Holland, P.
61edb7f8-e513-457a-bfb5-b9003e397589
Brittain, J.S.
10e3149e-7294-4111-8118-d1a010755744
Joint, C.
423119d0-8e94-47a6-8155-5245f6d4a144
Stein, J.F.
0a2d9b66-633d-40e2-8ac4-3dc4132679d7
Aziz, T.Z.
728d8821-5fa0-407f-a09f-5a52038ad170
Ray, N.J.
136d01d6-b4c3-4db9-a6c5-0d03d4ffa34c
Jenkinson, N.
6bf2c89f-decb-48ef-b1a1-a05779a64779
Wang, S.
a2223997-9f42-425b-b0c6-1bcb64d9b8fc
Holland, P.
61edb7f8-e513-457a-bfb5-b9003e397589
Brittain, J.S.
10e3149e-7294-4111-8118-d1a010755744
Joint, C.
423119d0-8e94-47a6-8155-5245f6d4a144
Stein, J.F.
0a2d9b66-633d-40e2-8ac4-3dc4132679d7
Aziz, T.Z.
728d8821-5fa0-407f-a09f-5a52038ad170

Ray, N.J., Jenkinson, N., Wang, S., Holland, P., Brittain, J.S., Joint, C., Stein, J.F. and Aziz, T.Z. (2008) Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Experimental Neurology, 213 (1), 108-113. (doi:10.1016/j.expneurol.2008.05.008).

Record type: Article

Abstract

Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz ([Brown et al., 2001], [Kuhn et al., 2004] and [Priori et al., 2004]) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (Kuhn et al., 2006). It has also been shown that improvements in motor symptoms after dopamine correlate with single unit activity in the beta range (Weinberger et al., 2006). We recorded local field potentials (LFPs) from the subthalamic nucleus of patients with Parkinson's disease (PD) after surgery to implant deep brain stimulating electrodes while they were on and off dopaminergic medication. As well as replicating Kuhn et al., using the same patients we were able to extend Weinberger et al. to show that LFP beta oscillatory activity correlated with the degree of improvement in bradykinesia/rigidity, but not tremor, after dopamine medication. We also found that the power of beta oscillatory activity uniquely predicted improvements in bradykinesia/rigidity, but again not tremor, after stimulation of the STN in a regression analysis. However improvements after STN stimulation related inversely to beta power, possibly reflecting the accuracy of the electrode placement and/or the limits of STN stimulation in patients with the greatest levels of beta oscillatory activity

Full text not available from this repository.

More information

Published date: September 2008
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 79203
URI: https://eprints.soton.ac.uk/id/eprint/79203
ISSN: 0014-4886
PURE UUID: ea961073-a908-42e1-a75b-885223544a82

Catalogue record

Date deposited: 15 Mar 2010
Last modified: 17 Jul 2019 00:12

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×