T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut
T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut
A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominance. V beta dominance was also shown in the T cells of the colonic lamina propria. Analysis of two separate regions of intestine from the same patient (5-100 cm apart) showed that T cells expressing a dominant V beta region were often present at both sites. In most patients, however, major biases in T cell V beta usage (two to 12-fold variation) were also apparent between the two sites. Analysis of V beta expression in human fetal intestine also showed considerable skewing, although the most common dominant V beta in postnatal intestine (V beta 22) was never predominant in fetal intestine. Patchy local variation in the expression of individual V beta s therefore occurs against a background of V beta dominance over large regions of the human gut. Furthermore the results from fetal gut show that factors other than luminal antigen control V beta expression in the gut.
190-195
Thomas, R.
6814ea6d-818e-4088-882f-2b87f0147d2a
Schurmann, G.
ba089296-7612-4e9a-9333-685d465da610
Lionetti, P.
5f7b9885-b7bc-4834-abee-70238aa842c8
Pender, S.L.F.
62528b03-ec42-41bb-80fe-48454c2c5242
MacDonald, T.T.
171334aa-638a-42b0-99f6-e860e2f0ca45
February 1996
Thomas, R.
6814ea6d-818e-4088-882f-2b87f0147d2a
Schurmann, G.
ba089296-7612-4e9a-9333-685d465da610
Lionetti, P.
5f7b9885-b7bc-4834-abee-70238aa842c8
Pender, S.L.F.
62528b03-ec42-41bb-80fe-48454c2c5242
MacDonald, T.T.
171334aa-638a-42b0-99f6-e860e2f0ca45
Thomas, R., Schurmann, G., Lionetti, P., Pender, S.L.F. and MacDonald, T.T.
(1996)
T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.
Gut, 38 (2), .
(doi:10.1136/gut.38.2.190).
Abstract
A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominance. V beta dominance was also shown in the T cells of the colonic lamina propria. Analysis of two separate regions of intestine from the same patient (5-100 cm apart) showed that T cells expressing a dominant V beta region were often present at both sites. In most patients, however, major biases in T cell V beta usage (two to 12-fold variation) were also apparent between the two sites. Analysis of V beta expression in human fetal intestine also showed considerable skewing, although the most common dominant V beta in postnatal intestine (V beta 22) was never predominant in fetal intestine. Patchy local variation in the expression of individual V beta s therefore occurs against a background of V beta dominance over large regions of the human gut. Furthermore the results from fetal gut show that factors other than luminal antigen control V beta expression in the gut.
This record has no associated files available for download.
More information
Published date: February 1996
Identifiers
Local EPrints ID: 79332
URI: http://eprints.soton.ac.uk/id/eprint/79332
ISSN: 1468-3288
PURE UUID: e699208e-a8b7-4cdb-8e91-1358431bd305
Catalogue record
Date deposited: 11 Mar 2010
Last modified: 14 Mar 2024 02:45
Export record
Altmetrics
Contributors
Author:
R. Thomas
Author:
G. Schurmann
Author:
P. Lionetti
Author:
T.T. MacDonald
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics