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MicroRNAs: key players in carcinogenesis and novel therapeutic targets

Mirnezami, A. H. F, Pickard, K., Zhang, L., Primrose, J. N. and Packham, G. (2008) MicroRNAs: key players in carcinogenesis and novel therapeutic targets European Journal of Surgical Oncology, 35, (4), pp. 339-347. (doi:10.1016/j.ejso.2008.06.006).

Record type: Article


MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype.
The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.

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Published date: April 2008
Keywords: MicroRNA, molecular profiling, cancer, clinical utility


Local EPrints ID: 79414
ISSN: 0748-7983
PURE UUID: 6515c80b-5f7e-4285-b7e6-e390ee3e31e7
ORCID for J. N. Primrose: ORCID iD

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Date deposited: 15 Mar 2010
Last modified: 18 Jul 2017 23:18

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Author: K. Pickard
Author: L. Zhang
Author: J. N. Primrose ORCID iD
Author: G. Packham

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