Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children
Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children
Objective: To test the hypothesis that maternal gestational diabetes increases cardiovascular risk markers in Indian children.
Research design and methods: Anthropometry, blood pressure, and glucose/insulin concentrations were measured in 514 children at 5 and 9.5 years of age (35 offspring of diabetic mothers [ODMs], 39 offspring of diabetic fathers [ODFs]). Children of nondiabetic parents were control subjects.
Results: At age 9.5 years, female ODMs had larger skinfolds (P < 0.001), higher glucose (30 min) and insulin concentrations, and higher homeostasis model assessment (HOMA) of insulin resistance and systolic blood pressure (P < 0.05) than control subjects. Male ODMs had higher HOMA (P < 0.01). Associations were stronger than at age 5 years. Female ODFs had larger skinfolds and male ODFs had higher HOMA (P < 0.05) than control subjects; associations were weaker than for ODMs. Associations between outcomes in control subjects and parental BMI, glucose, and insulin concentrations were similar for mothers and fathers.
Conclusions: The intrauterine environment experienced by ODMs increases diabetes and cardiovascular risk over genetic factors; the effects strengthen during childhood.
402-404
Krishnaveni, Ghattu V.
cd20fca7-d151-43b7-a7b4-d6051d6dd922
Veena, Sargoor R.
549cbba2-5ac1-4088-be37-4c1e656bddea
Hill, Jacqueline C.
2dcef0dd-8dfb-4891-b0d1-4c4cf2a9d4d4
Kehoe, Sarah
534e5729-632b-4b4f-8401-164d8c20aa26
Karat, Samuel C.
69af17ad-2c2a-464d-bb13-df1c40f51fc8
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
February 2010
Krishnaveni, Ghattu V.
cd20fca7-d151-43b7-a7b4-d6051d6dd922
Veena, Sargoor R.
549cbba2-5ac1-4088-be37-4c1e656bddea
Hill, Jacqueline C.
2dcef0dd-8dfb-4891-b0d1-4c4cf2a9d4d4
Kehoe, Sarah
534e5729-632b-4b4f-8401-164d8c20aa26
Karat, Samuel C.
69af17ad-2c2a-464d-bb13-df1c40f51fc8
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Krishnaveni, Ghattu V., Veena, Sargoor R., Hill, Jacqueline C., Kehoe, Sarah, Karat, Samuel C. and Fall, Caroline H.D.
(2010)
Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children.
Diabetes Care, 33 (2), .
(doi:10.2337/dc09-1393).
Abstract
Objective: To test the hypothesis that maternal gestational diabetes increases cardiovascular risk markers in Indian children.
Research design and methods: Anthropometry, blood pressure, and glucose/insulin concentrations were measured in 514 children at 5 and 9.5 years of age (35 offspring of diabetic mothers [ODMs], 39 offspring of diabetic fathers [ODFs]). Children of nondiabetic parents were control subjects.
Results: At age 9.5 years, female ODMs had larger skinfolds (P < 0.001), higher glucose (30 min) and insulin concentrations, and higher homeostasis model assessment (HOMA) of insulin resistance and systolic blood pressure (P < 0.05) than control subjects. Male ODMs had higher HOMA (P < 0.01). Associations were stronger than at age 5 years. Female ODFs had larger skinfolds and male ODFs had higher HOMA (P < 0.05) than control subjects; associations were weaker than for ODMs. Associations between outcomes in control subjects and parental BMI, glucose, and insulin concentrations were similar for mothers and fathers.
Conclusions: The intrauterine environment experienced by ODMs increases diabetes and cardiovascular risk over genetic factors; the effects strengthen during childhood.
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Published date: February 2010
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Local EPrints ID: 79423
URI: http://eprints.soton.ac.uk/id/eprint/79423
ISSN: 1935-5548
PURE UUID: 47593551-9b8e-43aa-86b0-e63b5ef5ea95
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Date deposited: 15 Mar 2010
Last modified: 14 Mar 2024 02:43
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Author:
Ghattu V. Krishnaveni
Author:
Sargoor R. Veena
Author:
Jacqueline C. Hill
Author:
Samuel C. Karat
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