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Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort

Fall, Caroline H. D., Sachdev, Harshpal Singh, Osmond, Clive, Lakshmy, Ramakrishnan, Biswas, Sushant Dey, Prabhakaran, Dorairaj, Tandon, Nikhil, Ramji, Siddharth, Reddy, K. Srinath, Barker, David J. P. and Bhargava, Santosh K. (2008) Adult metabolic syndrome abd impaired glucose tolerance are associated with different patterns of BMI from the New Delhi birth cohort Diabetes Care, 31, (12), pp. 2349-2356. (doi:10.2337/dc08-0911).

Record type: Article


Objective: the purpose of this study was to describe patterns of infant, childhood, and adolescent BMI and weight associated with adult metabolic risk factors for cardiovascular disease.

Research design and methods: we measured waist circumference, blood pressure, glucose, insulin and lipid concentrations, and the prevalence of metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III definition) in 1,492 men and women aged 26–32 years in Delhi, India, whose weight and height were recorded every 6 months throughout infancy (0–2 years), childhood (2–11 years), and adolescence (11 years–adult).

Results: men and women with metabolic syndrome (29% overall), any of its component features, or higher (greater than upper quartile) insulin resistance (homeostasis model assessment) had more rapid BMI or weight gain than the rest of the cohort throughout infancy, childhood, and adolescence. Glucose intolerance (impaired glucose tolerance or diabetes) was, like metabolic syndrome, associated with rapid BMI gain in childhood and adolescence but with lower BMI in infancy.

Conclusion: in this Indian population, patterns of infant BMI and weight gain differed for individuals who developed metabolic syndrome (rapid gain) compared with those who developed glucose intolerance (low infant BMI). Rapid BMI gain during childhood and adolescence was a risk factor for both disorders.

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Published date: December 2008


Local EPrints ID: 79893
ISSN: 1935-5548
PURE UUID: 351d9d6e-b219-4e84-b66e-30747c49c793
ORCID for Clive Osmond: ORCID iD

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Date deposited: 26 Mar 2010
Last modified: 18 Jul 2017 23:15

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Author: Harshpal Singh Sachdev
Author: Clive Osmond ORCID iD
Author: Ramakrishnan Lakshmy
Author: Sushant Dey Biswas
Author: Dorairaj Prabhakaran
Author: Nikhil Tandon
Author: Siddharth Ramji
Author: K. Srinath Reddy
Author: David J. P. Barker
Author: Santosh K. Bhargava

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