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Normative findings of electrically evoked compound action potential measurements uing the neural response telemetry of the nucleus CI24M cochlear implant system

Normative findings of electrically evoked compound action potential measurements uing the neural response telemetry of the nucleus CI24M cochlear implant system
Normative findings of electrically evoked compound action potential measurements uing the neural response telemetry of the nucleus CI24M cochlear implant system
One hundred and forty-seven adult recipients of the
Nucleus® 24 cochlear implant system, from 13 different
European countries, were tested using neural response
telemetry to measure the electrically evoked compound
action potential (ECAP), according to a standardised
postoperative measurement procedure. Recordings
were obtained in 96% of these subjects with this standardised procedure. The group results are presented in
terms of peak amplitude and latency, slope of the amplitude
growth function and ECAP threshold. The effects of
aetiological factors and the duration of deafness on the
ECAP were also studied. While large intersubject variability and intrasubject variability (across electrodes) were found, results fell within a consistent pattern and a normative range of peak amplitudes and latencies was established. The aetiological factors had little effect on the ECAP characteristics. However, age affected ECAP amplitude and slope of the amplitude growth function significantly; i.e., the amplitude is higher in the lowest age category (15–30 years). Principal component analysis of the ECAP thresholds shows that the thresholds
across 5 electrodes can be described by two factors
accounting for 92% of the total variance. The two factors
represent the overall level of the threshold profiles
(‘shift’) and their slopes across the electrode array (‘tilt’). Correlation between these two factors and the same factors describing the T- and C-levels appeared to be moderate, in the range of 0.5–0.6.
cochlear implant, neural response telemetry, electrically evoked compound action potential
1420-3030
105-116
Cafarelli Dees, D.
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Dillier, N.
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Lai, W.K.
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Von Wallenberg, E.
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Van Dijk, B.
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Akdas, F.
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Cullington, Helen E.
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Deggoujh, N.
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Frayssep, B.
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Grabels, S.
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Kiefert, J.
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Kiss, J.G.
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Lenarzu, T.
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Mairy, A.
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Maunev, S.
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Müller-Deilev, J.
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Pironq, J.P.
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Razzam, S.
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Tascheo, C.
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Thai-Vann, H.
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Tothx, F.
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Truyn, E.
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Uzielq, A.
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Smoorenburg, G.F.
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Cafarelli Dees, D.
cbea3cec-b497-4abe-b946-086de321f2fb
Dillier, N.
7c1d6999-4a6a-4709-9819-ee6f686c6771
Lai, W.K.
5c3a9593-4113-4c65-8c98-6b3c48db6063
Von Wallenberg, E.
f5dcc7a0-2517-47b6-ac1c-ee634241f4d0
Van Dijk, B.
449c6112-5885-413c-9b70-2a08964218bf
Akdas, F.
56928ca0-5613-45d5-9fcf-e7e370e2d930
Cullington, Helen E.
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Deggoujh, N.
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Frayssep, B.
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Grabels, S.
af2236f1-ab21-4f37-a0f3-295aa25b034a
Kiefert, J.
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Kiss, J.G.
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Lenarzu, T.
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Mairy, A.
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Maunev, S.
675aaa10-cfb2-4711-a1e3-bacacf2dc361
Müller-Deilev, J.
e2069694-5ba4-4dc1-be65-3a875a204ba6
Pironq, J.P.
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Razzam, S.
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Tascheo, C.
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Thai-Vann, H.
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Tothx, F.
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Truyn, E.
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Uzielq, A.
641ceab2-820e-47cb-a15f-6e054a856900
Smoorenburg, G.F.
8e09af32-4033-44c0-81e3-00daa19b9a0c

Cafarelli Dees, D., Dillier, N., Lai, W.K., Von Wallenberg, E., Van Dijk, B., Akdas, F., Cullington, Helen E., Deggoujh, N., Frayssep, B., Grabels, S., Kiefert, J., Kiss, J.G., Lenarzu, T., Mairy, A., Maunev, S., Müller-Deilev, J., Pironq, J.P., Razzam, S., Tascheo, C., Thai-Vann, H., Tothx, F., Truyn, E., Uzielq, A. and Smoorenburg, G.F. (2005) Normative findings of electrically evoked compound action potential measurements uing the neural response telemetry of the nucleus CI24M cochlear implant system. Audiology and Neuro-Otology, 10 (2), 105-116. (doi:10.1159/000083366).

Record type: Article

Abstract

One hundred and forty-seven adult recipients of the
Nucleus® 24 cochlear implant system, from 13 different
European countries, were tested using neural response
telemetry to measure the electrically evoked compound
action potential (ECAP), according to a standardised
postoperative measurement procedure. Recordings
were obtained in 96% of these subjects with this standardised procedure. The group results are presented in
terms of peak amplitude and latency, slope of the amplitude
growth function and ECAP threshold. The effects of
aetiological factors and the duration of deafness on the
ECAP were also studied. While large intersubject variability and intrasubject variability (across electrodes) were found, results fell within a consistent pattern and a normative range of peak amplitudes and latencies was established. The aetiological factors had little effect on the ECAP characteristics. However, age affected ECAP amplitude and slope of the amplitude growth function significantly; i.e., the amplitude is higher in the lowest age category (15–30 years). Principal component analysis of the ECAP thresholds shows that the thresholds
across 5 electrodes can be described by two factors
accounting for 92% of the total variance. The two factors
represent the overall level of the threshold profiles
(‘shift’) and their slopes across the electrode array (‘tilt’). Correlation between these two factors and the same factors describing the T- and C-levels appeared to be moderate, in the range of 0.5–0.6.

Full text not available from this repository.

More information

Published date: 12 January 2005
Keywords: cochlear implant, neural response telemetry, electrically evoked compound action potential
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 80510
URI: https://eprints.soton.ac.uk/id/eprint/80510
ISSN: 1420-3030
PURE UUID: b7c6eeb9-4f41-4dea-9a46-1eaedb2d81bf
ORCID for Helen E. Cullington: ORCID iD orcid.org/0000-0002-5093-2020

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Date deposited: 24 Mar 2010
Last modified: 06 Jun 2018 12:37

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Contributors

Author: D. Cafarelli Dees
Author: N. Dillier
Author: W.K. Lai
Author: E. Von Wallenberg
Author: B. Van Dijk
Author: F. Akdas
Author: N. Deggoujh
Author: B. Frayssep
Author: S. Grabels
Author: J. Kiefert
Author: J.G. Kiss
Author: T. Lenarzu
Author: A. Mairy
Author: S. Maunev
Author: J. Müller-Deilev
Author: J.P. Pironq
Author: S. Razzam
Author: C. Tascheo
Author: H. Thai-Vann
Author: F. Tothx
Author: E. Truyn
Author: A. Uzielq
Author: G.F. Smoorenburg

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