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N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]

Murphy, Frank, Waung, Julian, Collins, Jane, Arthur, Michael J.P., Nagase, Hideaki, Mann, Derek, Benyon, R. Christopher and Iredale, John P. (2004) N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] Comparative Hepatology, 3, (Suppl 1), p.S8. (doi:10.1186/1476-5926-2-S1-S8).

Record type: Article

Abstract

Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix metalloproteinase (MMP) inhibition. This has led to further study of novel substrates for MMPs that might impact on HSC survival. N-Cadherin is known to mediate cell-cell contacts in fibroblasts. In this study we demonstrate that N-Cadherin is expressed by activated rat HSC. Furthermore, during apoptosis of HSC, the N-Cadherin is cleaved into smaller fragments. Apoptosis of HSC may be inhibited by TIMP-1. This is associated with reduced fragmentation of N-Cadherin. N-Cadherin may have an important role in supporting HSC survival while N-Cadherin cleavage may play a part in promoting HSC apoptosis in recovery from liver fibrosis.

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Published date: 14 January 2004
Additional Information: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells Tucson, Arizona, USA, 25–29 August, 2002.

Identifiers

Local EPrints ID: 8191
URI: http://eprints.soton.ac.uk/id/eprint/8191
ISSN: 1476-5926
PURE UUID: 4e371558-d654-410f-8491-9d31a74a2eb1

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Date deposited: 10 Aug 2004
Last modified: 17 Jul 2017 17:12

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Contributors

Author: Frank Murphy
Author: Julian Waung
Author: Jane Collins
Author: Michael J.P. Arthur
Author: Hideaki Nagase
Author: Derek Mann
Author: R. Christopher Benyon
Author: John P. Iredale

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