Endocrinology in pregnancy: influence of maternal vitamin D status on obstetric outcomes and the foetal skeleton
Endocrinology in pregnancy: influence of maternal vitamin D status on obstetric outcomes and the foetal skeleton
Vitamin D status is increasingly associated with wide ranging clinical outcomes. There is now a wealth of observational studies reporting on its associations with obstetric complications, including preeclampsia, gestational diabetes and mode and timing of delivery. The findings are inconsistent and currently there is a lack of data from high quality intervention studies to confirm a causal role for vitamin D in these outcomes. This is similarly true with regards to fetal development, including measures of fetal size and skeletal mineralisation. Overall, there is an indication of possible benefits of vitamin D supplementation during pregnancy for offspring birthweight, calcium concentrations and bone mass, and for reduced maternal pre-eclampsia. However, for none of these outcomes is the current evidence base conclusive, and the available data justify the instatement of high-quality randomised placebo controlled trials in a range of populations and health care settings to establish potential efficacy and safety of vitamin D supplementation to improve particular outcomes.
vitamin D, pregnancy, pre-eclampsia, gestational diabetes, osteoporosis, epidemiology
1-33
Moon, R.J.
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Harvey, N.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Moon, R.J.
954fb3ed-9934-4649-886d-f65944985a6b
Harvey, N.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Moon, R.J., Harvey, N. and Cooper, C.
(2015)
Endocrinology in pregnancy: influence of maternal vitamin D status on obstetric outcomes and the foetal skeleton.
European journal of endocrinology, .
(doi:10.1530/EJE-14-0826).
(PMID:25862787)
Abstract
Vitamin D status is increasingly associated with wide ranging clinical outcomes. There is now a wealth of observational studies reporting on its associations with obstetric complications, including preeclampsia, gestational diabetes and mode and timing of delivery. The findings are inconsistent and currently there is a lack of data from high quality intervention studies to confirm a causal role for vitamin D in these outcomes. This is similarly true with regards to fetal development, including measures of fetal size and skeletal mineralisation. Overall, there is an indication of possible benefits of vitamin D supplementation during pregnancy for offspring birthweight, calcium concentrations and bone mass, and for reduced maternal pre-eclampsia. However, for none of these outcomes is the current evidence base conclusive, and the available data justify the instatement of high-quality randomised placebo controlled trials in a range of populations and health care settings to establish potential efficacy and safety of vitamin D supplementation to improve particular outcomes.
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e-pub ahead of print date: 10 April 2015
Keywords:
vitamin D, pregnancy, pre-eclampsia, gestational diabetes, osteoporosis, epidemiology
Organisations:
Human Development & Health
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Local EPrints ID: 376021
URI: http://eprints.soton.ac.uk/id/eprint/376021
ISSN: 0804-4643
PURE UUID: df4f3d42-0f8a-42ff-a49a-891b3b46aae1
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Date deposited: 21 Apr 2015 13:31
Last modified: 18 Mar 2024 02:58
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R.J. Moon
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