Tris-ureas as transmembrane anion transporters
Tris-ureas as transmembrane anion transporters
Nine tris-ureas receptors (L1-L9) have been synthesised and shown to coordinate to a range of anionic guests both by 1H NMR titration techniques and single crystal X-ray structural analysis. The compounds have been shown to be capable of mediating the exchange of chloride and nitrate and also chloride and bicarbonate across POPC or POPC:cholesterol 7:3 vesicle bilayer membranes at low transporter loadings. An interesting dependency of anion transport on the nature of the cation is evidence to suggest that a M+/Cl- cotransport process may also contribute to the release of chloride from the vesicles.
11892-11897
Olivari, Martina
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Montis, Riccardo
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Berry, Stuart N.
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Karagiannidis, Louise E.
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Coles, Simon J.
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Horton, Peter N.
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Mapp, Lucy K.
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Gale, Phil A.
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Caltagirone, Claudia
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Olivari, Martina
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Montis, Riccardo
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Berry, Stuart N.
c7287fbf-5845-4f28-b3ab-bf3a35e3fd9f
Karagiannidis, Louise E.
625706f1-9870-43dd-9ee1-b981c60562b4
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Mapp, Lucy K.
b90136ce-37b0-464a-8934-d44a8c2d7e48
Gale, Phil A.
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Caltagirone, Claudia
9148afed-6af0-4fcd-b30e-daa3d7765dc0
Olivari, Martina, Montis, Riccardo, Berry, Stuart N., Karagiannidis, Louise E., Coles, Simon J., Horton, Peter N., Mapp, Lucy K., Gale, Phil A. and Caltagirone, Claudia
(2016)
Tris-ureas as transmembrane anion transporters.
Dalton Transactions, 45, .
(doi:10.1039/C6DT02046A).
Abstract
Nine tris-ureas receptors (L1-L9) have been synthesised and shown to coordinate to a range of anionic guests both by 1H NMR titration techniques and single crystal X-ray structural analysis. The compounds have been shown to be capable of mediating the exchange of chloride and nitrate and also chloride and bicarbonate across POPC or POPC:cholesterol 7:3 vesicle bilayer membranes at low transporter loadings. An interesting dependency of anion transport on the nature of the cation is evidence to suggest that a M+/Cl- cotransport process may also contribute to the release of chloride from the vesicles.
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Paper_amended.docx
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Accepted/In Press date: 30 June 2016
e-pub ahead of print date: 1 July 2016
Organisations:
Organic Chemistry: SCF
Identifiers
Local EPrints ID: 397711
URI: http://eprints.soton.ac.uk/id/eprint/397711
ISSN: 0300-9246
PURE UUID: b30f3dd7-1ff1-44c6-a1c6-b5a2e3f1e8f8
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Date deposited: 05 Jul 2016 09:16
Last modified: 15 Mar 2024 05:43
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Contributors
Author:
Martina Olivari
Author:
Riccardo Montis
Author:
Stuart N. Berry
Author:
Louise E. Karagiannidis
Author:
Peter N. Horton
Author:
Lucy K. Mapp
Author:
Phil A. Gale
Author:
Claudia Caltagirone
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