A Monte Carlo exchange algorithm for finding near-optimal designs under model contamination
At International Biometric Society British Region Conference.
16 - 17 Sep 2003.
A Monte Carlo exchange algorithm is presented for finding efficient designs under bias-based criteria. The true model is assumed to differ from the model to be fitted by an additive contamination term, which is considered to be a realisation of a random variable. This results in the bias for any given design also being a random variable. Any available prior knowledge can be used to inform the distribution of the contamination. Criteria for design selection are described whose objective functions are based upon properties of the bias distribution.
These criteria are implemented in an exchange algorithm, where efficient designs are found by exchanging points between the design and a candidate list of possible points. The objective functions are approximated via Monte Carlo simulation within the algorithm. Although for some criteria a single approximation can be used for all exchanges of design and candidate points, for others a simulation is required for each swap. Therefore the approach is highly computationally intensive.
Examples are used to demonstrate the designs produced using the algorithm and criteria. These designs tend to have more distinct support points than traditional optimal designs and hence are of more practical value. The adequacy of the simulation is considered for each example, and the sensitivity of the designs to the prior information is investigated.
Conference or Workshop Item
|Venue - Dates:
||International Biometric Society British Region Conference, 2003-09-16 - 2003-09-17
|16 September 2003||Published|
||06 Jun 2005
||16 Apr 2017 23:27
|Further Information:||Google Scholar|
Actions (login required)