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Integrated systems for rapid point of care (PoC) blood cell analysis

Integrated systems for rapid point of care (PoC) blood cell analysis
Integrated systems for rapid point of care (PoC) blood cell analysis
Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeration in a single, integrated system. Results of microfluidic 3-part differential leukocyte (granulocyte, lymphocyte and monocyte) counts, together with erythrocyte and thrombocyte (platelet) counts, in human blood are shown and corroborated with results from hospital clinical laboratory analysis.
1473-0197
1249-1255
van Berkel, Cees
148b8dd1-6357-4308-81af-1ee11d287e99
Gwyer, James D.
a996644a-37b0-4bc6-b47e-4e553f7c92a7
Deane, Steve
1eaa8cd2-4ac0-4a96-9e38-5396137d22e3
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Holloway, Judith
f22f45f3-6fc8-4a4c-bc6c-24add507037c
Hollis, Veronica
98fb298c-a05a-4ddc-9b4e-500762bfa007
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
van Berkel, Cees
148b8dd1-6357-4308-81af-1ee11d287e99
Gwyer, James D.
a996644a-37b0-4bc6-b47e-4e553f7c92a7
Deane, Steve
1eaa8cd2-4ac0-4a96-9e38-5396137d22e3
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Holloway, Judith
f22f45f3-6fc8-4a4c-bc6c-24add507037c
Hollis, Veronica
98fb298c-a05a-4ddc-9b4e-500762bfa007
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

van Berkel, Cees, Gwyer, James D., Deane, Steve, Green, Nicolas G, Holloway, Judith, Hollis, Veronica and Morgan, Hywel (2011) Integrated systems for rapid point of care (PoC) blood cell analysis. Lab on a Chip, 11 (7), 1249-1255. (doi:10.1039/C0LC00587H). (PMID:21331413)

Record type: Article

Abstract

Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeration in a single, integrated system. Results of microfluidic 3-part differential leukocyte (granulocyte, lymphocyte and monocyte) counts, together with erythrocyte and thrombocyte (platelet) counts, in human blood are shown and corroborated with results from hospital clinical laboratory analysis.

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J56_vanBerkel_Gwyer_Deane_Green_Holloway_Hollis_Morgan_Lab_On_A_Chip_2011.pdf - Other
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More information

Published date: 7 April 2011
Organisations: Infection Inflammation & Immunity, Electronics & Computer Science, Engineering Sciences

Identifiers

Local EPrints ID: 181025
URI: https://eprints.soton.ac.uk/id/eprint/181025
ISSN: 1473-0197
PURE UUID: f1ff08a2-db3b-4d9c-bcd8-83d83360e7bf
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for Judith Holloway: ORCID iD orcid.org/0000-0002-2268-3071
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 13 Apr 2011 10:20
Last modified: 15 Aug 2019 00:49

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