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On-chip high-speed sorting of micron-sized particles for high-throughput analysis

On-chip high-speed sorting of micron-sized particles for high-throughput analysis
On-chip high-speed sorting of micron-sized particles for high-throughput analysis
A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by focussing particles into the central streamline of the main flow channel using dielectrophoretic focussing. At the sorting junction (T- or Y-junction) two sets of electrodes produce a small dielectrophoretic force that pushes the particle into one or other of the outlet channels, where they are carried under the pressure-driven fluid flow to the outlet. For a 40mm wide and high channel, it is shown that 6micron diameter particles can be deflected at a rate of 300particles/s. The principle of a fully automated sorting device is demonstrated by separating fluorescent from non-fluorescent latex beads.
129-134
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Sandison, Mairi
e3191c23-e1b2-4127-b418-61f34a235e1c
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Sandison, Mairi
e3191c23-e1b2-4127-b418-61f34a235e1c
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Holmes, David, Sandison, Mairi, Green, Nicolas G and Morgan, Hywel (2005) On-chip high-speed sorting of micron-sized particles for high-throughput analysis. IEE Proceedings - Nanobiotechnology, 152 (4), 129-134. (doi:10.1049/ip-nbt:20050008).

Record type: Article

Abstract

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by focussing particles into the central streamline of the main flow channel using dielectrophoretic focussing. At the sorting junction (T- or Y-junction) two sets of electrodes produce a small dielectrophoretic force that pushes the particle into one or other of the outlet channels, where they are carried under the pressure-driven fluid flow to the outlet. For a 40mm wide and high channel, it is shown that 6micron diameter particles can be deflected at a rate of 300particles/s. The principle of a fully automated sorting device is demonstrated by separating fluorescent from non-fluorescent latex beads.

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Published date: August 2005
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 262072
URI: https://eprints.soton.ac.uk/id/eprint/262072
PURE UUID: 9309110d-4fbf-4157-94d8-60caefa0338d
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 08 Mar 2006
Last modified: 17 Sep 2019 00:52

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