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Dynamical approaches to modeling developmental gene regulatory networks

Dynamical approaches to modeling developmental gene regulatory networks
Dynamical approaches to modeling developmental gene regulatory networks
The network of interacting regulatory signals within a cell comprises one of the most complex and powerful computational systems in biology. Gene regulatory networks play a key role in transforming the information encoded in a genome into morphological form. To achieve this feat, gene regulatory networks must respond to and integrate environmental signals with their internal dynamics in a robust and coordinated fashion. The highly dynamic nature of this process lends itself to interpretation and analysis in the language of dynamical models. Modelling provides a means of systematically untangling the complicated structure of gene regulatory networks, a framework within which to simulate the behaviour of reconstructed systems and, in some cases, suites of analytic tools for exploring that behaviour and its implications. This review provides a general background to the idea of treating a regulatory network as a dynamical system, and describes a variety of different approaches that have been taken to the dynamical modelling of gene regulatory networks.
gene regulatory networks, dynamical systems, modeling, simulation
131-142
Geard, Nicholas
e9933f78-10b8-4454-8c8d-c2c75e040346
Willadsen, Kai
6d274613-b4a0-492d-8241-d7fe62d5e21a
Geard, Nicholas
e9933f78-10b8-4454-8c8d-c2c75e040346
Willadsen, Kai
6d274613-b4a0-492d-8241-d7fe62d5e21a

Geard, Nicholas and Willadsen, Kai (2009) Dynamical approaches to modeling developmental gene regulatory networks. Birth Defects Research Part C: Embryo Today: Reviews, 87 (2), 131-142. (Submitted)

Record type: Article

Abstract

The network of interacting regulatory signals within a cell comprises one of the most complex and powerful computational systems in biology. Gene regulatory networks play a key role in transforming the information encoded in a genome into morphological form. To achieve this feat, gene regulatory networks must respond to and integrate environmental signals with their internal dynamics in a robust and coordinated fashion. The highly dynamic nature of this process lends itself to interpretation and analysis in the language of dynamical models. Modelling provides a means of systematically untangling the complicated structure of gene regulatory networks, a framework within which to simulate the behaviour of reconstructed systems and, in some cases, suites of analytic tools for exploring that behaviour and its implications. This review provides a general background to the idea of treating a regulatory network as a dynamical system, and describes a variety of different approaches that have been taken to the dynamical modelling of gene regulatory networks.

Text GeardWilladsen.pdf - Accepted Manuscript
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More information

Submitted date: 2009
Keywords: gene regulatory networks, dynamical systems, modeling, simulation
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 267400
URI: https://eprints.soton.ac.uk/id/eprint/267400
PURE UUID: d8dc55e4-6d68-4abd-a67b-20058c334ead

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Date deposited: 26 May 2009 09:57
Last modified: 24 Oct 2018 16:31

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